SynthesisFrontiers in medicine2025
Research hotspots and trends in unexplained recurrent spontaneous abortion (URSA) from 2014 to 2024: a bibliometric analysis.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- MAFF promotes decidual stromal cell senescence by suppressing NRF2-mediated antioxidant responses in recurrent pregnancy loss.Journal of assisted reproduction and genetics · 2026Article
- miR-146a/b-5p-IRAK1-NF-κB Axis Regulates Unexplained Recurrent Spontaneous Abortion.Journal of molecular recognition : JMR · 2026Article
- Gestational sac ellipticity index measured at ≤ 7 weeks' gestation as a predictor of first-trimester embryonic demise: a retrospective cohort study.Archives of gynecology and obstetrics · 2026Article
- Risk assessment of drug-associated miscarriage using XGBoost and SHAP explainability: a real-world pharmacovigilance analysis based on the FAERS database.Frontiers in pharmacology · 2026Article
- Research overview and hotspots in the field of recurrent miscarriage: A literature-mining study.Frontiers in medicine · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Recurrent spontaneous abortion (RSA) represents a significant challenge in obstetrics and reproductive medicine. Causative factors in 40%-50% of RSA couples remain unknown, a condition termed unexplained recurrent spontaneous abortion (URSA). This study employed bibliometric analysis to elucidate global research trends and identify key areas of interest in URSA. Methods: We utilized the Web of Science Core Collection (WoSCC), including Science Citation Index Expanded (SCI-EXPANDED) and Social Sciences Citation Index (SSCI), as our data source. Our search encompassed all publications on URSA published between 1 January 2014 and 30 October 2024. Following rigorous removal of duplicates, we retained 586 relevant publications, including 532 original articles and 54 reviews. We conducted bibliometric analysis using CiteSpace, VOSviewer and Microsoft Excel. Results: Analysis of annual publications and their citations demonstrated significant growth over the last 10 years. China, the United States and Iran emerged as the most productive countries in the field. Author distribution indicated the absence of a cohesive core author group, suggesting a dispersed research community. The top five cited publications included one prospective observational study, one randomized controlled trial, two reviews, and one immunohistochemistry study, focusing on the etiology, interventions, and therapies of URSA. Keyword cluster analysis identified six categories, with the top three keywords being "expression," "polymorphisms," and "regulatory T-cells." Conclusion: This bibliometric analysis reveals three key research domains over the last decade in URSA: immunological mechanism and therapies, genetic mechanism, and anticoagulation therapies. While these areas have advanced our understanding, limitations persist in etiological heterogeneity and therapeutic inconsistencies. Future studies should prioritize rigorous multicenter trials with phenotypic stratification, and multi-omics approaches for mechanistic insights. Enhanced global collaboration and interdisciplinary integration are essential to transition from empirical management to evidence-based precision medicine in URSA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.