Advanced lung cancer inflammation index and short-term mortality in sepsis: a retrospective analysis.

Background: Sepsis is a notable cause of death and poor prognosis in the intensive care unit (ICU). Presents an ambiguous association between advanced lung cancer inflammation (ALI) and short-term lethality in sepsis patients. The purpose of this study is to explore this relationship. Methods: This retrospective study identified sepsis cases from the MIMIC-IV 3.0 dataset. Multivariable Cox regression analysis was used to evaluate the relationship between ALI and the risks of 30-day all-cause mortality (ACM) and ICU mortality. Kaplan-Meier (K-M) curves and log-rank tests were employed for survival analysis. Restricted cubic spline (RCS) regression was employed to explore the nonlinear association between ALI and mortality risk. Subgroup and sensitivity analyses were performed to confirm the reliability of the results and to evaluate the incremental effect of ALI on the prediction of short-term mortality. Results: A total of 4,147 sepsis cases were included in this study, with a 30-day ACM rate of 26.7% and a 30-day ICU mortality rate of 18.5%. In the completely adjusted Cox model, patients in the highest quartile of log2-ALI had a 38% lower risk of 30-day ACM (HR = 0.62, Conclusion: This research found that lower levels of ALI were notably linked to higher 30-day ACM and 30-day ICU mortality in sepsis patients, warranting further verification through prospective studies.