Evidence map›Paper›PMID 40438303›Full record

ArticleNeuroimage. Reports2025

Radiation-induced brain injury in non-human primates: A dual tracer PET study with [

Naresh Damuka, George W Schaaf, Mack Miller, Caleb Bradley, Bhuvanachandra Bhoopal, Ivan Krizan, Krishna K Gollapelli, Christopher T Whitlow, J Mark Cline, Kiran K Solingapuram Sai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroimage. Reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Imaging microtubule dynamics: A new frontier in biomarker development for neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Naresh DamukaDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
George W SchaafDepartment of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0001-7129-9474
Mack MillerDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Caleb BradleyDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0003-1151-0041
Bhuvanachandra BhoopalDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-2129-009X
Ivan KrizanDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Krishna K GollapelliDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Christopher T WhitlowDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
J Mark ClineDepartment of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0003-4844-1238
Kiran K Solingapuram SaiDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-6442-5169

Funding

Somatostatin analogues as countermeasures against intestinal radiation toxicityU19AI067798 · NIAID · DUKE UNIVERSITY · PI CHAO, NELSON J. · 2005 to 2024
$82.1M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
The Wake Forest Nonhuman Primate Radiation Survivor CohortU01AI150578 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI J. MARK CLINE · 2020 to 2026
$23.7M
CTSA UM1 Program at Wake ForestUM1TR004929 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamy D Ard, KRISTIE L FOLEY · 2024 to 2026
$11.9M
NCATS NIH HHS UM1 TR004929NIAID NIH HHS U01 AI150578NIAID NIH HHS U19 AI067798NIA NIH HHS P30 AG072947
6 · The paper itself

Abstract

Radiation-induced brain injury (RIBI) and Alzheimer's disease (AD) share key pathological features, including β-amyloid (Aβ) plaque formation and microtubule (MT) destabilization, both contributing to neurodegeneration. This pilot study assessed Aβ deposition and MT stability in non-human primates (NHPs) exposed to ionizing radiation, utilizing [

Indexed as

Aβ depositionMicrotubule destabilizationNeurodegenerationPET imagingRadiation-induced brain injuryRadiotracers

Identifiers

PMID40438303
PMCPMC12108029

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.