ReviewFrontiers in behavioral neuroscience2025
Sex differences in anxiety and depression: insights from adult rodent models of chronic stress and neural plasticity.
Review in Frontiers in behavioral neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Sex Differences in Depression: Adult Cytogenesis as Potential Target for Precision Psychiatry.Cells · 2026Review
- The central amygdala corticotropin releasing factor system regulates anxiety-like behavior in an age- and sex- dependent manner in rats.Addiction neuroscience · 2026Article
- Social and Anxiety-Like Behaviors Are Affected in Juvenile Mice With Gli2Brain and behavior · 2026Article
- Of mice and gender: considering gender norms in rodent models.Biology of sex differences · 2026Review
- The WAG/Rij Rat Model of Depression Comorbid with Absence Epilepsy: Sex Differences and Neurochemical Mechanisms.International journal of molecular sciences · 2026Article
- From Monoamines to Systems Psychiatry: Rewiring Depression Science and Care (1960s-2025).Biomedicines · 2025Article
- Effect of Sacubitril/Valsartan, Ivabradine, and Captopril on Anxiety-like Behavior in Spontaneously Hypertensive Rats.International journal of molecular sciences · 2025Article
- Sex and Circadian Rhythm Dependent Behavioral Effects of Chronic Stress in Mice and Modulation of Clock Genes in the Prefrontal Cortex.International journal of molecular sciences · 2025Article
- GABA-producingMicrobiome research reports · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
The often co-morbid conditions of depression and anxiety are the most common mental illnesses and are more prevalent among females than males. Chronic stress paradigms in rodents serve as valuable preclinical models for investigating the factors contributing to these disorders and their neural underpinnings. A variety of chronic stressors are associated with the development of sexually differentiated effects on anxiety- and depressive-like responses in rodents. This review summarizes and discusses common behavioral tasks used to assess anxiety-like (e.g., elevated plus maze, open field) and depressive-like (e.g., sucrose preference, forced swim) behaviors in rodents and discusses evidence of sex differences in these responses. Preclinical chronic stress models also aid in identifying potential mechanisms underlying behavioral changes, including dendritic synaptic alterations in neural circuits affected by stress. Robust sex differences have been observed in stress-responsive brain regions such as the prefrontal cortex, hippocampus, and amygdala. Therefore, applying chronic stress paradigms and assessing their neural effects in rodents may provide crucial insights into the biological basis of sexually differentiated mental illnesses in humans.
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Registered trials
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