ArticleGE Portuguese journal of gastroenterology2025
Hypereosinophilic Syndrome Presenting with Digestive Symptoms in Pediatric Patients: A Portuguese Tertiary Hospital Case Series.
Article in GE Portuguese journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Hypereosinophilic syndrome (HES) is an uncommon disorder characterized by persistent peripheral eosinophilia and involvement of different organs. It is rare in pediatric ages. Cases Presentation: We present 3 pediatric patients diagnosed with HES exhibiting digestive symptoms. Clinical records, laboratory results, imaging studies, and treatment plans were systematically collected and analyzed. All patients underwent an extensive etiological investigation to exclude infectious, autoimmune, and tumoral causes. Treatment with corticosteroids resulted in symptomatic and analytical improvement in all patients. Conclusion: This case series highlights the complexity of pediatric HES presenting with digestive manifestations. The diverse clinical presentation underscores the importance of considering HES in the differential diagnosis of unexplained gastrointestinal symptoms in children. Diagnostic and treatment challenges demand a multidisciplinary approach. These insights enhance our knowledge of this rare condition, enlarging the limited literature on this subject in the pediatric population.
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