Evidence map›Paper›PMID 40438119›Full record

ReviewFrontiers in immunology2025

The intestinal interferon system and specialized enterocytes as putative drivers of HIV latency.

Rachel L Creighton, Sean M Hughes, Florian Hladik, Germán G Gornalusse

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Tenofovir, Interferon Pathways, and Mucosal Immunity: Implications for People Living With HIV.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rachel L CreightonDepartment of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA, United States.
Sean M HughesDepartment of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA, United States.
Florian HladikDepartment of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA, United States.
Germán G GornalusseDepartment of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA, United States.

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
NCCIH Supplement to NCATS/CTSA Program for KL2 Scholars - M. SoddersKL2TR002317 · NCATS · UNIVERSITY OF WASHINGTON · PI Christy Michelle McKinney · 2017 to 2026
$14.5M
Role of intestinal microfold (M) cells in creating a hotspot environment for HIV reservoir persistence and reactivationR01AI184122 · NIAID · UNIVERSITY OF WASHINGTON · PI German Gustavo Gornalusse · 2024 to 2026
$2.5M
NCATS NIH HHS KL2 TR002317NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI184122
6 · The paper itself

Abstract

The barrier to HIV cure is the HIV reservoir, which is composed of latently infected CD4

Indexed as

EnterocytesHIV-1HIV InfectionsInterferonsVirus LatencyAnimalsCD4-Positive T-LymphocytesHumansIntestinal MucosaSignal TransductionVirus ActivationInterferonsenterocytesHIV latencyinterferoninterferon stimulated gene (ISG)microfold cell (M-cell)

Identifiers

PMID40438119
PMCPMC12116432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.