ArticleFrontiers in public health2025
Individual and joint effects of exposure to phthalates and the risk of cardiovascular disease in the chronic kidney disease population: NHANES 2005-2018.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Age-Specific Association Between Urinary Phthalate Metabolites and Diabetes Mellitus: Findings from the Korean National Environmental Health Survey Cycle 4 (2018-2020).Healthcare (Basel, Switzerland) · 2026Article
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2 authors.
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Abstract
Background: There is a lack of studies on the relationship between urinary phthalate metabolites (UPMs) and cardiovascular disease (CVD) prevalence in adults suffering from chronic kidney disease (CKD). We intended to examine the relationship between UPMs and the prevalence of CVD in people with CKD. Methods: The research utilized data in the National Health and Nutrition Examination Survey (NHANES) 2005-2018. We employed three statistical models-a generalized linear regression model, a weighted quantile sum (WQS) regression model, and a Bayesian kernel machine regression (BKMR) model. Results: We included 834 CKD participants finally. In the generalized linear regression model, the prevalence of CVD was higher in individuals with MiBP (OR 1.86; 95% CI 1.08-3.18; P for trend = 0.022), MCNP (OR 1.85; 95% CI 1.18-2.91; P for trend = 0.011), MBP (OR 1.68; 95% CI 1.02-2.76; P for trend = 0.041) and MECPP (OR 2.22; 95% CI 1.28-3.86; P for trend = 0.008) in the highest tertile compared to those in the lowest tertile. In the WQS model, the WQS index was significantly positively associated with CVD (OR 1.44; 95% CI 1.04-1.99; Conclusion: The results indicated that phthalate exposure was linked to an elevated risk of cardiovascular disease and highlighted the need to reduce plastic use among the CKD population.
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