SynthesisPsychological medicine2025
Cumulative exposure to childhood adversity and risk of adult psychosis: a dose-response meta-analysis.
Synthesis in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The severity of dissociation and dissociative phenomena in non-affective psychosis: a systematic review and meta-analyses.BMC psychiatry · 2026Pooled it
- The dynamic interplay between anxiety-related, psychotic, and suicidal experiences: a qualitative study.BMC psychiatry · 2025Trial
- Measures matter: assessing childhood maltreatment and emotion dysregulation in a transdiagnostic sample.European journal of psychotraumatology · 2026Article
- Developmental Trauma as a Prognostic Factor for Later Psychotic Disorder in an Adolescent Clinical Cohort: A 20-Year Follow Up Study.Acta psychiatrica Scandinavica · 2026Article
- Stress and Sleep Dynamics in Young Adults with Psychotic-Like Experiences Across Daily Life.Schizophrenia bulletin · 2026Article
- Integrating biological pathway polygenic scores and trauma in psychosis: findings from the EU-GEI study.Translational psychiatry · 2026Article
- Heterogeneous Trajectories of Prosocial Behavior in Adolescents with Adverse Childhood Experiences: The Roles of Empathy and Social support.Journal of youth and adolescence · 2026Article
- Psychological and behavioral mechanisms linking childhood trauma profiles to voice-related distress in schizophrenia spectrum disorders: latent class, mediation, and conditional process analyses.Psychological medicine · 2026Article
- Evaluating psychosis-specific effects of trauma exposure in early-onset and adult-onset psychosis.Psychological medicine · 2026Article
- Plasma Multiomics Links Early-Life Adversity to Disease and Cardiometabolic Health: A Population-Based Cohort Study.Journal of the American Heart Association · 2026Article
- 'Therapy or no therapy, I'm still going to have unusual experiences [ … ] but it has [helped] the way that I feel and cope.' A qualitative exploration of service user experiences of EMDRp and TF-CBTp in the 'REducing psychosiS risk by TARgeting Trauma' study.Frontiers in psychiatry · 2026Article
- Do Obsessive-Compulsive Symptoms Increase the Risk of Developing Psychosis? A Systematic Review and Meta-analysis.Schizophrenia bulletin open · 2026Article
- Adverse childhood experiences and late-life depression in older Chinese adults: the mediating roles of sleep disorders and chronic diseases.BMC geriatrics · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPast meta-analyses have confirmed robust associations between childhood traumatic experiences and the risk of psychosis. However, the dose-response relationship between cumulative adversity exposure and psychosis risk observed in some, but not all, previous studies in this area has not been specifically scrutinized or substantiated via recommended meta-analytic methods. This meta-analysis aimed to synthesize the available evidence on dose-response effects between childhood trauma and psychosis outcomes.
methodsPsycINFO, PubMed, EMBASE, Web of Science, CNKI, and WANFANG were searched from inception to July 2024 to identify observational studies reporting odds ratios for psychosis outcomes across multiple levels of childhood trauma exposure. Dose-response effects were extracted from eligible studies and synthesized via robust error meta-regression analyses.
resultsTwenty-one studies comprising 59,975 participants were included in the meta-analysis. A significant nonlinear relationship was observed between the number of childhood adversities and the risk of future psychosis experiences (
conclusionsThis meta-analysis provides robust evidence for a dose-response relationship between cumulative childhood adversity and psychosis risk, with nonlinear patterns suggestive of an accelerating, more pronounced, risk at higher levels of trauma exposure. These findings underscore the importance of considering childhood traumatic experiences as a putative and potentially causative risk factor for psychotic experiences, as well as early prevention and intervention efforts targeting childhood adversity to reduce the risk of psychosis.
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