Evidence map›Paper›PMID 40437900›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

Predictive Factors and Treatment Effects of Neuromodulators in Chronic Refractory Cough.

Katrina Sandham, Sarah Emmett, Duy Duong Nguyen, Catherine Madill, Daniel Novakovic

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In one paragraph

Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katrina SandhamDr Liang Voice Program, University of Sydney Voice Research Laboratory, Discipline of Speech Pathology, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID 0009-0001-4664-3357
Sarah EmmettDr Liang Voice Program, University of Sydney Voice Research Laboratory, Discipline of Speech Pathology, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0001-9179-9388
Duy Duong NguyenDr Liang Voice Program, University of Sydney Voice Research Laboratory, Discipline of Speech Pathology, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0001-8097-8938
Catherine MadillDr Liang Voice Program, University of Sydney Voice Research Laboratory, Discipline of Speech Pathology, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0001-8114-1427
Daniel NovakovicDr Liang Voice Program, University of Sydney Voice Research Laboratory, Discipline of Speech Pathology, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0003-3839-1353

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ImportanceChronic refractory cough (CRC) has a negative impact on the quality of life of sufferers and is difficult to treat. Although previous studies have documented various treatment methods for CRC, no treatment method has proven fully effective.ObjectiveThis study investigated the treatment efficacy and adverse effects of neuromodulators (NM), Amitriptyline and Gabapentin, in the treatment of CRC, and the factors that predicted outcomes.DesignProspective data review.SettingPrivate otolaryngology clinic.ParticipantsThis study included 103 successive patients (72 female, 31 male) during the period between 2013 and 2023. Mean age of patients was 56.6 years (standard deviation: 13.5; range: 21 to 83).InterventionAll patients received treatment using NM, including Amitriptyline and Gabapentin.Main Outcome MeasuresCough Severity Index (CSI) and the Newcastle Laryngeal Hypersensitivity Questionnaire (NLHQ). The minimal important difference (MID) in CSI was calculated and used as the threshold to determine response to NM treatment.ResultsA MID of 7 or more in CSI was regarded as a response to NM χ

Indexed as

AmitriptylineCoughGabapentinNeurotransmitter AgentsAdultAgedAged, 80 and overChronic DiseaseFemaleHumansMaleMiddle AgedQuality of LifeTreatment OutcomeYoung AdultAmitriptylineGabapentinNeurotransmitter Agentsamitriptylinechronic refractory coughgabapentinlaryngeal sensory dysfunctionneuromodulator

Identifiers

PMID40437900
PMCPMC12123101

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.