ArticleBJOG : an international journal of obstetrics and gynaecology2025
Risk of Spontaneous Preterm Birth in a Subsequent Pregnancy After Full Dilatation Caesarean Birth: A Nationwide Cohort Study.
Article in BJOG : an international journal of obstetrics and gynaecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Uterine closure after cesarean delivery: surgical technique, biological rationale, and clinical implications.American journal of obstetrics and gynecology · 2026Review
- Risk of Spontaneous Preterm Birth in a Subsequent Pregnancy After Full Dilatation Caesarean Birth: A Nationwide Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo investigate the association between caesarean birth in the second stage of labour and the risk of spontaneous preterm birth in a subsequent pregnancy.
designNationwide register-based cohort study.
settingThe Danish Medical Birth Registry and The Danish National Patient Register from 1997 to 2021. POPULATION: Women with at least two consecutive births (index birth and subsequent birth) where the index birth was a term singleton.
methodsWomen with spontaneous preterm subsequent birth were compared according to the mode of index birth, including vaginal, prelabour caesarean, first stage caesarean and second-stage caesarean. Statistical analysis was performed using multiple logistic regression.
main outcome measureSpontaneous birth before 37 + 0 gestational weeks.
resultsA total of 376 414 women met the inclusion criteria. Distribution of mode of index birth was vaginal 318 117 (84.5%), prelabour caesarean 15 373 (4.1%), first stage caesarean 37 547 (10.0%) and second-stage caesarean 5377 (1.4%), respectively. The rate of subsequent preterm birth was 1.7%. Compared to vaginal birth, a second-stage caesarean was associated with an increased risk of preterm birth in a subsequent pregnancy (adjusted odds ratio [aOR] 1.46, 95% confidence interval [CI] 1.21-1.77). Similarly, compared to first stage caesarean, a second-stage caesarean was associated with an increased risk of preterm birth in the subsequent pregnancy, with an aOR of 1.41 (95% CI 1.15-1.74).
conclusionSecond-stage caesarean in a previous term pregnancy is associated with an increased risk of spontaneous preterm birth in a subsequent pregnancy.
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