ArticleBrain and behavior2025
White Matter Microstructure Alterations in Older Adults With Dyslipidemia Associated With Cognitive and Locomotor Dysfunction Evaluated Using Neurite Orientation Dispersion and Density Imaging.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Plasma complex lipids in relation to cortical thickness and brain volumes: results from the population-based Rhineland study.Lipids in health and disease · 2026Article
- Alterations of structural-functional connectivity coupling in older adults with depressive symptoms.Psychological medicine · 2025Article
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13 authors.
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Abstract
introductionDiffusion tensor imaging (DTI) studies have shown white matter (WM) microstructural alterations in individuals with dyslipidemia; however, DTI indices are not specific to WM pathology. However, neurite orientation dispersion and density imaging (NODDI) provides more specific measurements of WM microstructure. This study aimed to evaluate dyslipidemia-related WM microstructure alterations and their association with cognitive and motor functions using NODDI.
methodsThe DTI and NODDI metrics were analyzed through tract-based spatial statistics between 24 older adults with dyslipidemia (low-density lipoprotein ≥140 mg/dL, high-density lipoprotein <40 mg/dL, and triglyceride ≥150 mg/dL, or under treatment) and 18 healthy control participants (HCs). Partial correlation tests were performed between diffusion magnetic resonance imaging measures and lipid profiles, cognitive, or locomotor scores in the dyslipidemia and HC groups separately. WM volumetry between HCs and dyslipidemia groups was also assessed. Age, gender, intracranial volume, and years of education were included as covariates in all analyses. A false discovery rate-corrected P value of <0.05 was considered statistically significant.
resultsIndividuals with dyslipidemia exhibited a notably reduced neurite density index (NDI) in several WM areas, including the posterior and superior corona radiata, the body, the genu, and the splenium of the corpus callosum, as well as the bilateral anterior and posterior internal capsule, compared with HCs. In the dyslipidemia group, lower NDI was significantly correlated with lower scores on the stand-up test and the Japanese version of the Montreal Cognitive Assessment. No significant differences were found in DTI metrics or WM volumes between dyslipidemia individuals and HCs.
conclusionOur findings suggest that NODDI can serve as a biomarker for assessing WM microstructural alterations in older adults with dyslipidemia. Particularly, NODDI indicates a lower intra-axonal volume, which may suggest axonal loss associated with dyslipidemia, and correlates with cognitive and locomotor function decline.
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