Evidence map›Paper›PMID 40437817›Full record

ArticleAnimal models and experimental medicine2025

A hepatoprotective experiment on taro vegetable (Colocasia esculenta (L.) Schott) flower employing animal models by mitigating oxidative stress.

Mahathir Mohammad, Fahmida Tasnim Richi, Rabiul Hossain, Md Arafat, Pair Ahmed Jiko, Nazim Uddin Emon, Sayed Al Hossain Rabbi, Tirtha Khastagir, Md Hemayet Hossain, Safaet Alam

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In one paragraph

Article in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mahathir MohammadDepartment of Chemistry, Chittagong University of Engineering & Technology, Chittagong, Bangladesh.ORCID 0000-0002-4169-899X
Fahmida Tasnim RichiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.ORCID 0000-0002-7271-4219
Rabiul HossainDepartment of Pharmacy, University of Science and Technology, Chittagong, Bangladesh.
Md ArafatDepartment of Biochemistry and Biotechnology, University of Science and Technology Chittagong, Chittagong, Bangladesh.
Pair Ahmed JikoDepartment of Chemistry, Chittagong University of Engineering & Technology, Chittagong, Bangladesh.
Nazim Uddin EmonDepartment of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, Chittagong, Bangladesh.ORCID 0000-0001-7567-4796
Sayed Al Hossain RabbiDepartment of Chemistry, Government City College, Chattogram, National University, Chattogram, Bangladesh.
Tirtha KhastagirDepartment of Pathology, Marine City Medical College, Chattogram, Bangladesh.
Md Hemayet HossainChemical Research Division, BCSIR Dhaka Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.ORCID 0000-0001-8759-9279
Safaet AlamChemical Research Division, BCSIR Dhaka Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.ORCID 0000-0002-1831-2278

Funding

Bangladesh Council of Scientific and Industrial Research (BCSIR) 39.02.0000.011.14.157.2022/172
6 · The paper itself

Abstract

backgroundColocasia esculenta (L.) Schott, known as the taro vegetable, possesses various beneficial effects and is traditionally used in folk medicine. This study explores the ameliorative antioxidant and hepatoprotective effect of a methanolic extract of the C. esculenta flower (ME-CEF) against oxidative damage and hepatotoxicity in mice.

methodsThe antioxidant efficacy of ME-CEF was assessed using 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay. The hepatoprotective effect was investigated by an assessment of liver injury indicators (amino transferase [ALT], aspartate amino transferase [AST], alkaline phosphatase [ALP], bilirubin, creatinine) and normalizing lipid profiles (cholesterol [CHO], triglyceride [TG], high-density lipoprotein [HDL], and low-density lipoprotein [LDL]) along with histopathological study and antioxidant enzymes (CAT). A phytochemical analysis, both qualitative and quantitative, was conducted, including gas chromatography-tandem mass spectrometry (GC-MS/MS) analysis and an in silico molecular docking study.

resultsThe Result Showed that ME-CEF Possesses Moderate ABTS and DPPH Scavenging Activity with IC

conclusionBased on these results, our findings strongly recommend the medicinal use of the plant, highlighting its antioxidant and hepatoprotective potentials.

Indexed as

Chemical and Drug Induced Liver InjuryColocasiaOxidative StressPlant ExtractsProtective AgentsAnimalsAntioxidantsCarbon TetrachlorideFlowersLiverMiceToxicity TestsAntioxidantsCarbon TetrachloridePlant ExtractsProtective Agentsanimal modelsantioxidantColocasia esculentahepatoprotectivehistopathologytaro vegetable

Identifiers

PMID40437817
PMCPMC12431575

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.