Evidence map›Paper›PMID 40437782›Full record

ReviewJournal of experimental botany2026

Exploring the role of DNA damage response in seed priming to uncover key players for multi-stress tolerance.

Anca Macovei, Andrea Pagano, Conrado Duenas, Susana Araujo, Alma Balestrazzi

Abstract readReview
In one paragraph

Review in Journal of experimental botany, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Seed biology: the birth of plant life.Journal of experimental botany · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anca MacoveiDepartment of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy.ORCID 0000-0002-4455-6321
Andrea PaganoDepartment of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy.ORCID 0000-0003-1998-5201
Conrado DuenasDepartment of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy.ORCID 0009-0002-5657-7987
Susana AraujoLaboratório Colaborativo Montanhas de Investigação (MORE), Bragança, Portugal.ORCID 0000-0003-2823-088X
Alma BalestrazziDepartment of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy.ORCID 0000-0003-2003-4120

Funding

European Union-NextGenerationEUItalian Ministry of University and Research F13C22000720007National Recovery and Resilience Plan
6 · The paper itself

Abstract

Combined climatic stressors result in cumulative damage and unpredictable shocks to seed systems. Seed priming, a pre-sowing technique used to enhance seed vigour, is a key tool to face climate change. Priming agents boost the DNA damage response during early seed imbibition, preserving genome integrity and ensuring germination. Based on these premises, to what extent could the DNA damage response support the seed response to multiple stresses? How could seed priming enhance DNA repair to better fight combined stressors? How far are we from understanding the mechanisms for multiple stress tolerance that can contribute to improved resilience in seeds? The state of the art is critically discussed considering the scanty knowledge on this topic, highlighting the complex scenario of multi-factorial stress combinations. Case studies showing the efficacy of seed priming in promoting multiple stress response are reviewed, integrating the role of cross-stress tolerance, target germplasm (from major to orphan crops), and the contribution of advanced omics/phenotyping tools. Expanding current knowledge in seed biology, by focusing on the impact of multiple climatic stressors, is a challenge since there are still relevant open questions concerning the way in which the DNA damage response can be utilized in seeds that must be addressed.

Indexed as

DNA DamageSeedsStress, PhysiologicalClimate ChangeGerminationDNA damage responsegerminationmulti-factorial stress combinationpre-germinative metabolismseed priming

Identifiers

PMID40437782
PMCPMC13022554

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.