ArticleMolecular plant2025
ERFVIIs as transducers of oxygen-sensing in the evolution of land plant response to hypoxia.
Article in Molecular plant, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Duet between sugars and hormones: The molecular dialogue fine-tuning hypoxia acclimation in plants.Journal of integrative plant biology · 2026Review
- Reactive oxygen species and oxidative signalling in plants.Essays in biochemistry · 2026Review
- Chemical priming of hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves flooding tolerance.Plant physiology · 2026Article
- Regulatory architecture of high-altitude adaptation in Artemisia: from signal perception to specialized metabolism.Plant cell reports · 2026Review
- HNature · 2026Article
- Prolyl hydroxylase-dependent proteolysis enables the orthogonal hypoxia responses in plants.Nature communications · 2026Article
- Cross-Regulation of Metabolic and Immune Pathways in Plants Under Hypoxic Conditions.Plants (Basel, Switzerland) · 2026Review
- A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Integrating multiomic resources and gene expression studies to identify candidates for engineering climate-resilientFrontiers in plant science · 2026Review
- Non-seed plant research in the spotlight.Biology open · 2025Article
- Roles of ROS and NO in Plant Responses to Individual and Combined Salt Stress and Waterlogging.Antioxidants (Basel, Switzerland) · 2025Review
- Single-cell transcriptome atlas unveils transcriptional regulation networks of banana root tips in response toHorticulture research · 2025Article
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7 authors.
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Abstract
The transcriptional response to low oxygen (hypoxia) in flowering plants is mediated by group VII Ethylene Response Factor (ERFVII) transcription factors, whose proteolysis is oxygen-dependent via the PLANT CYSTEINE OXIDASE (PCO) N-degron pathway. However, when and how this hypoxia response evolved in land plants remains unknown. In this study, we investigated the conservation and divergence of transcriptional responses to hypoxia across major land plant clades. We found that the induction of gene functions associated with glycolysis and fermentation is part of a conserved response across all land plant divisions.Evolutinary analyses suggest that ERFVIIs emerged in the last common ancestor of vascular plants with true roots, coinciding with the evolution of oxygen-dependent destabilization mechanisms that regulate hypoxia-adaptive genes. Proteins from other ERF groups have been independently recruited multiple times in different clades as substrates of the PCO N-degron pathway. Taken together, our results demonstrate that the response of land plants to hypoxia has been refined in derived clades through the evolution of ERFVIIs as transcriptional transducers, which occurred concurrently with the emergence of vascular systems and roots as foraging structures in hypoxic soils.
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