SynthesisJournal of applied toxicology : JAT2025
Do Gadolinium-Based Contrasts Represent a High Risk for Genotoxicity in Mammalian Cells? A Systematic Review.
Synthesis in Journal of applied toxicology : JAT, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Do Gadolinium-Based Contrasts Represent a High Risk for Genotoxicity in Mammalian Cells? A Systematic Review.Journal of applied toxicology : JAT · 2025Pooled it
- Chromosomal Instability and Telomere Attrition in Systemic Sclerosis: A Historical Perspective.Genes · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The scientific rationale for this review stems from the increasing global use of gadolinium-based contrast agents in medical imaging and the concerns over the long-term environmental accumulation of gadolinium waste, which may pose biological risks. The primary objective was to determine whether gadolinium exposure induces genetic damage in mammalian cells, regardless of the assay method used, and to assess the quality of the studies available in the literature. Genotoxicity was measured through assays such as the micronucleus test, comet assay, chromosomal aberration, and sister chromatid exchange. A total of 17 studies were included being 11 studies (out of 17) with positive genotoxic effects, suggesting that gadolinium can induce DNA damage. Most of the studies (12 out of 17) were rated as "strong" or "moderate" in quality, providing reliable evidence for these findings. This review advances the current understanding of gadolinium's potential health risks by highlighting its genotoxic effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.