ArticleItalian journal of pediatrics2025
Analysis of clinical characteristics and risk factors for Staphylococcus aureus disseminated infection secondary to acute osteoarticular infections in children.
Article in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- How Should Bacteriological Sampling Be Stratified in Paediatric Septic Arthritis? A Narrative Review with a Proposed Risk-Stratified Framework.Antibiotics (Basel, Switzerland) · 2026Review
- Osteomyelitis.Nature reviews. Disease primers · 2026Review
- Additive-Manufactured S53P4@PCL Composite Scaffolds Functionalized with Aptamers and Antibacterial Exosomes for Rapid Bacterial Capture and Killing.Journal of functional biomaterials · 2026Article
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6 authors.
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Abstract
backgroundThe aim of this study was to investigate the risk factors associated with Staphylococcus aureus (S. aureus) disseminated infection (DSAI) that occurs secondarily to acute osteoarticular infections (OAI) in children.
methodsA retrospective analysis of 131 pediatric patients with acute OAI (July 2012-March 2024) was conducted. Patients were categorized into a DSAI group (33 cases) and a non-DSAI group (98 cases). Data analyzed included age, gender, pediatric intensive care unit (PICU) admission, surgical delay, initial symptoms, highest pre-hospital fever, inflammatory markers, pathogen type (MSSA/MRSA), bacteremia, antibiotic duration, postoperative fever length, surgeries (≥ 2), hospital stay, and prognosis.
resultsDSAI primarily affected the lungs, brain, and thorax, with femur and hip joints being the most involved OAI sites. Fever (45.45%) and limb swelling/pain (42.42%) were common symptoms. The DSAI group showed significantly higher CRP levels, bacteremia incidence, MRSA infections, PICU admissions, surgical delays, ≥ 2 surgeries, longer postoperative fever, prolonged hospital stays, and worse prognosis (P < 0.05). No significant differences were found in age, gender, pre-admission time, initial symptoms, highest fever, WBC count, ESR, antibiotic duration, or neutrophil percentage (P > 0.05). Logistic regression identified bacteremia (OR: 32.232, 95% CI: [2.558-406.068], P = 0.007), CRP > 162.375 mg/L (OR: 7.499, 95% CI: [2.044-27.513], P = 0.002), and surgical delay > 9.50 days (OR: 7.462, 95% CI: [1.828-30.459], P = 0.005) as independent risk factors.
conclusionDSAI complicates OAI, leading to a severe course and poor prognosis. High vigilance and early intervention are crucial for pediatric patients with these risk factors.
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