SynthesisEuropean journal of medical research2025
Exploring the effects of doxorubicin on survival rates in glioma patients: a comprehensive systematic review.
Synthesis in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlioma is still one of the most aggressive and common types of brain and central nervous system cancer, with few effective treatment options. Despite progress in therapy, there is a requirement for new methods to enhance patient outcomes. Doxorubicin (DOX), a type of anthracycline that has been proven to be effective in different cancers, encounters difficulties in treating glioma because of the blood-brain barrier. This systematic review is intended to assess the effects of DOX on the survival and quality of life of glioma patients.
methodsWe conducted a thorough search and found 1576 records, from which 10 studies met our inclusion criteria. These studies, published between 1973 and 2023, were examined for overall survival (OS), progression-free survival (PFS), median time to progression (mTTP), response rate, and toxicity profiles.
resultsThe studies included in the analysis showed that OS ranged from 6 to 18.5 months, indicating potential improved outcomes with liposomal and PEGylated forms of DOX. PFS rates varied from 15 to 58%, and mTTP ranged from 11 to 39.83 weeks. Response rates varied from 19 to 88%, and while DOX was generally well-tolerated, some hematological and non-hematological toxicities were observed. DOX shows promise in prolonging survival and slowing glioma progression, especially with advanced delivery methods.
conclusionsHowever, variations in research, small sample sizes, and lack of uniformity highlight the need for further investigation. Overcoming these limitations in future studies is crucial to maximize DOX's effectiveness in glioma treatment and improve patient outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.