Evidence map›Paper›PMID 40437606›Full record

ArticleJournal of cardiothoracic surgery2025

A case of diagnosis and treatment of mediastinal Langerhans cytosis.

Yumeng Niu, Lei Xian, Yi Wang, Yourong Chen, Yifei Lu, Daying Liang

Abstract readCase Reports
In one paragraph

Article in Journal of cardiothoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yumeng NiuDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital of Guangxi Medical University, No.166 Da Xuedong Road Nanning Guangxi, Nanning Guangxi, 530007, China.
Lei XianDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital of Guangxi Medical University, No.166 Da Xuedong Road Nanning Guangxi, Nanning Guangxi, 530007, China. 15369308097@163.com.
Yi WangDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital of Guangxi Medical University, No.166 Da Xuedong Road Nanning Guangxi, Nanning Guangxi, 530007, China.
Yourong ChenDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital of Guangxi Medical University, No.166 Da Xuedong Road Nanning Guangxi, Nanning Guangxi, 530007, China.
Yifei LuDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital of Guangxi Medical University, No.166 Da Xuedong Road Nanning Guangxi, Nanning Guangxi, 530007, China.
Daying LiangDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital of Guangxi Medical University, No.166 Da Xuedong Road Nanning Guangxi, Nanning Guangxi, 530007, China.

Funding

National Natural Science Foundation of China 82060509
6 · The paper itself

Abstract

backgroundLangerhans cell histiocytosis (LCH) is a rare disease. It mainly involves abnormal proliferation and aggregation of Langerhans cells, a type of cell of the immune system.Langerhans cytosis is more common in the bone, but it has rarely been reported in the mediastinum. CASE PRESENTATION: We present a case of mediastinal thymus tumor presented with Langerhans cell histiocytosis. A 40-year-old female patient presented with left chest and back pain in April 2024. Imaging revealed abnormal signal lesions on the patient's left rib and anterior superior mediastinum. The clinical diagnosis was bone destruction and mediastinal space occupation, and the postoperative pathological diagnosis was Langerhans cell histiocytosis.

conclusionsLangerhans cytosis is characterized by mediastinal and thymus occupation and is relatively rare in clinical practice. For patients who tolerate surgery for a single or local lesion, surgical removal of the primary lesion should be considered. However, for patients with multiple lesions or distant metastases, clinicians should evaluate whether surgery will benefit the patient. After surgical treatment, targeted therapy or immunotherapy should be performed.

Indexed as

Histiocytosis, Langerhans-CellMediastinumThymus NeoplasmsAdultFemaleHumansTomography, X-Ray ComputedLangerhans cell histiocytosis (LCH)MediastinumThymus

Identifiers

PMID40437606
PMCPMC12121284

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.