Evidence map›Paper›PMID 40437589›Full record

ArticleItalian journal of pediatrics2025

Demographic and clinical characteristics of children and adolescents with headache and/or dizziness and hemodynamic responses to head-up tilt test.

Runmei Zou, Shuo Wang, Fang Li, Ping Liu, Donglei Liao, Liqun Liu, Jing Liu, Hong Cai, Yuwen Wang, Cheng Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Treatment of Headache in Children and Adolescents with POTS.Current pain and headache reports · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Runmei ZouDepartment of Pediatric Cardiovasology, The Second Xiangya Hospital, Children's Medical Center, Central South University, No.139 Renmin Middle Road, Changsha, Hunan, 410011, China.
Shuo WangDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Fang LiDepartment of Pediatric Cardiovasology, The Second Xiangya Hospital, Children's Medical Center, Central South University, No.139 Renmin Middle Road, Changsha, Hunan, 410011, China.
Ping LiuDepartment of Pediatric Cardiovasology, The Second Xiangya Hospital, Children's Medical Center, Central South University, No.139 Renmin Middle Road, Changsha, Hunan, 410011, China.
Donglei LiaoDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Liqun LiuDepartment of Pediatric Neurology, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Jing LiuThe Children's Cardiothoracic Vascular Center, Chenzhou First People's Hospital, Chenzhou, Hunan, 423000, China.
Hong CaiDepartment of Pediatric Cardiovasology, The Second Xiangya Hospital, Children's Medical Center, Central South University, No.139 Renmin Middle Road, Changsha, Hunan, 410011, China.
Yuwen WangDepartment of Pediatric Cardiovasology, The Second Xiangya Hospital, Children's Medical Center, Central South University, No.139 Renmin Middle Road, Changsha, Hunan, 410011, China.
Cheng WangDepartment of Pediatric Cardiovasology, The Second Xiangya Hospital, Children's Medical Center, Central South University, No.139 Renmin Middle Road, Changsha, Hunan, 410011, China. wangcheng2nd@csu.edu.cn.ORCID http://orcid.org/0000-0002-7120-0654

Funding

Natural Science Foundation of Hunan Province 2023JJ30812Science Fund for Distinguished Young Scholars of Hunan Province 2023SK4018
6 · The paper itself

Abstract

backgroundHeadache and dizziness are common symptoms in children and adolescents, but the causes of headache/dizziness in most pediatric patients are not clearly defined. We intended to investigate the demographic and clinical features of pediatric patients with headache and/or dizziness and responses to head-up tilt test (HUTT).

methodsThe demographic data and medical records of children and adolescents, with a primary complaint of headache and/or dizziness and undergoing HUTT between January 2001 and June 2023, were retrospectively reviewed and analyzed. Children and adolescents with headache and/or dizziness secondary to fever, trauma, or other obvious etiology were excluded. For those with positive responses to HUTT, the symptom score and HUTT responses were collected after treatment at follow-up.

resultsAmong 2709 patients with unexplained headache and/or dizziness, 1080 (39.87%) cases presented positive responses to HUTT, whereas 1629 (60.13%) cases had negative responses. Among patients with positive responses, 930 (34.33%) cases presented a response of vasovagal syncope, 143 (5.28%) cases of postural orthostatic tachycardia syndrome, and 7 (0.26%) cases of orthostatic hypertension. Multivariate Logistic regression analysis demonstrated that females, older age, and low body mass index percentile increased the risk of being positive responses. At follow-up, HUTT results of 236 patients were collected, among which 131 (55.51%) cases turned negative HUTT responses and had headache/dizziness symptoms improved after treatment targeted autonomic dysfunction.

conclusionHUTT can be applied to evaluate the autonomic function of children and adolescents with headache and/or dizziness and assess the treatment responses in those patients with autonomic dysfunction.

Indexed as

DizzinessHeadacheHemodynamicsTilt-Table TestAdolescentChildChild, PreschoolFemaleHumansMalePostural Orthostatic Tachycardia SyndromeRetrospective StudiesSyncope, VasovagalAutonomic functionChildrenDizzinessHeadacheHead-up Tilt test

Identifiers

PMID40437589
PMCPMC12121244

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.