Evidence map›Paper›PMID 40437548›Full record

ArticleBMC medicine2025

Slowing fetal growth velocity from the mid-trimester may signal increased risks of perinatal morbidity and mortality: a retrospective cohort study.

Chloe Jamieson-Grigg, Pawel Kalinowski, Stephen Tong, Esther Turner, Sarah A Banting, Susan P Walker, Teresa M MacDonald

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chloe Jamieson-GriggDepartment of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, VIC, Australia.
Pawel KalinowskiTranslational Neurodegeneration Group, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.
Stephen TongDepartment of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, VIC, Australia.
Esther TurnerDepartment of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, VIC, Australia.
Sarah A BantingDepartment of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, VIC, Australia.
Susan P Walker *Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, VIC, Australia.
Teresa M MacDonald *Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, VIC, Australia. teresa.mary.macdonald@gmail.com.

Funding

National Health and Medical Research Council 2017897National Health and Medical Research Council 2025553Norman Beischer Medical Research Foundation Innovation GrantRoyal Australian and New Zealand College of Obstetricians and Gynaecologists Arthur Wilson Memorial ScholarshipStillbirth Centre for Research Excellence Future Leaders' Fellowship
6 · The paper itself

Abstract

backgroundUndetected fetal growth restriction is a major risk factor for stillbirth. Detecting small babies is a cornerstone of obstetric care, but we fail to detect most uteroplacental insufficiency impairing fetal growth, and most small fetuses. Slowing fetal growth is thought to flag fetal growth restriction, but uncertainty about what constitutes poor growth has hindered clinical translation. We aim to validate slowing fetal growth velocity as a measurable risk factor for adverse pregnancy outcomes, and to better define growth velocity assessment to aid clinical interpretation.

methodsWe performed a retrospective cohort study of ultrasound and birth outcome data. All patients with singleton pregnancies and at least two ultrasound fetal size assessments between 18

resultsAmong 24,395 pregnancies, most first scans were routine mid-trimester ultrasounds (median 20

conclusionsSlowing fetal growth velocity identifies pregnancies at increased risk of poor outcomes. A slowing growth rate < - 0.13 z-scores/week may represent a pragmatic clinical threshold. Fetal growth rate between scans could be incorporated into ultrasound reporting to better identify fetuses at risk.

Indexed as

Fetal DevelopmentFetal Growth RetardationPerinatal MortalityAdultFemaleHumansInfant, NewbornPregnancyPregnancy OutcomePregnancy Trimester, SecondRetrospective StudiesRisk FactorsStillbirthUltrasonography, PrenatalAdverse perinatal outcomeAppropriate-for-gestational-ageFetal growth restrictionFetal growth velocityPerinatal mortalitySlowing fetal growthSmall-for-gestational-ageStillbirthUteroplacental insufficiency

Identifiers

PMID40437548
PMCPMC12121231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.