ReviewStem cell research & therapy2025
Application of induced pluripotent stem cells in the conservation of endangered animals.
Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Review
- Article
- Review
- The role of emerging assisted reproductive technologies in the conservation of neotropical wild mammals - challenges, advances and perspectives.The Journal of reproduction and development · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The accelerating biodiversity crisis urgently demands innovative approaches that transcend traditional conservation strategies, which are often constrained by genetic bottlenecks and disease risks. Induced pluripotent stem cells (iPSCs) technology emerges as a transformative solution, enabling non-invasive genetic preservation and multi-pathway species recovery. This review synthesizes advances in reprogramming somatic cells from endangered species into iPSCs through integration-free strategies, such as mRNA, Sendai virus, episomal systems, adenoviruses and chemical induction, thereby reducing genomic instability. We highlight breakthroughs in differentiating iPSCs into functional gametes for assisted reproduction and blastoids formation for embryonic reconstruction, circumventing donor oocyte dependency and genetic homogeneity risks. Despite challenges in lineage specification and epigenetic fidelity, combining iPSC biobanking with ecosystem management enables large-scale genetic rescue. By combining these technologies with ethical frameworks and habitat restoration, the plasticity of cells may be transformed into population resilience, potentially redefining biodiversity conservation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.