ArticleBMC veterinary research2025
Efficacy of caudal epidural injection of Xylazine-Lidocaine HCl and detomidine-lidocaine HCl in domestic horses (Equus ferus caballus).
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The current study was prepared to compare the efficacy of xylazine-lidocaine HCl and detomidine-lidocaine HCl following caudal epidural injection in horses, evaluating sedation, analgesia, physiological parameters, and hemato-biochemical values. This study was applied to six healthy adult horses (300-350 kg, > 4 years of age). The horses were randomly divided into two equal groups. Group 1 (seven horses) received xylazine (0.17 mg/kg bwt) + lidocaine HCl (0.06 mg/kg bwt), while Group 2 received detomidine (0.03 mg/kg bwt) + lidocaine HCl (0.06 mg/kg bwt) via caudal epidural injection. Perineal analgesia and sedation (onset time and duration) were assessed before administration and at 15, 30, 60, 90, and 120 min post-administration. Concurrently, heart rate, respiratory rate, rectal temperature, and hemato-biochemical values were recorded. The sedative duration of detomidine was longer than that of xylazine (94 ± 0.96 vs. 85 ± 0.94 min). Both detomidine and xylazine induced complete bilateral perineal analgesia in all horses. Analgesia onset was slightly faster and duration longer in detomidine-treated horses compared to xylazine, and these values are for onset of analgesia (11.79 ± 1.15 vs. 14.46 ± 0.92 min). Significant heart rate depression was observed in Group 2, in which both white blood cell count (WBC) and packed cell volume (PCV) percentage showed significant decreases. Conclusion and Clinical Relevance: The findings of this study suggest that epidural administration of detomidine-lidocaine HCl results in more effective and longer-lasting perineal analgesia compared to xylazine-lidocaine HCl.
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