Evidence map›Paper›PMID 40437496›Full record

ArticleBMC medicine2025

Interpreting results from biomarker-guided clinical trials: avoiding "negative" or "failed" terminology.

Nurulamin M Noor, Haiyan Zheng, David S Robertson, Joshua Savage, Christina Yap, Andrea L Jorgensen, James M S Wason, MRC-NIHR Trial Methodology Research Partnership (TMRP) Precision Medicine Working Group

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nurulamin M NoorDepartment of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Haiyan ZhengDepartment of Mathematical Sciences, University of Bath, Bath, UK.
David S RobertsonMRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
Joshua SavageCancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham, Birmingham, UK.
Christina YapClinical Trials and Statistics Unit, The Institute of Cancer Research, London, UK.
Andrea L JorgensenDepartment of Health Data Science, University of Liverpool, Liverpool, UK.
James M S WasonBiostatistics Research Group, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK. james.wason@newcastle.ac.uk.
MRC-NIHR Trial Methodology Research Partnership (TMRP) Precision Medicine Working Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biomarker-drivenBiomarker-guidedBiomarkersBiomarker-stratifiedClinical trialsPrecision medicine

Identifiers

PMID40437496
PMCPMC12121256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.