ArticleBMC oral health2025
Lipid droplet accumulation impairs osseointegration by disturbing the osteogenesis-osteoclasis balance on titanium implant surface in hyperlipidemia.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Simulated Body Fluids for Dental Implant Corrosion: A Practical Guide.Dentistry journal · 2026Review
- Age-dependent association between lifestyle oxidative balance score and bone mineral density in children and adolescents: evidence from the NHANES 2015-2018.Frontiers in physiology · 2025Article
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2 authors.
Funding
Abstract
backgroundEffective osseointegration is a crucial factor for the success of implant restoration, and hyperlipidemia significantly impairs osseointegration. However, the underlying in vivo mechanisms remain unclear. This study aimed to investigate the impact and molecular mechanisms of lipid droplet accumulation on osteogenesis-osteoclasis balance on titanium (Ti) implant surface.
methodsIn vivo, hyperlipidemia mice receiving local injections of Wnt3a or N-acetyl-L-cysteine (NAC) in peri-implant tissue were used to assess osseointegration, lipid droplet accumulation, and osteogenesis-osteoclasis balance by Micro-CT, hard tissue slicing and staining, H&E staining, TRAP staining, as well as immunofluorescence (IF) staining. The in situ oxidative damage of cells obtained from the extracted implant surfaces was detected by transmission electron microscopy and enzyme-linked immunosorbent assay. In vitro, bone marrow mesenchymal stem cells (BMMSCs) were cultured on Ti sheet with intermittent treatment of NAC. The relationship between lipid droplets and oxidative damage was detected by IF staining of BODIPY, GRP78, DCFH-DA, EdU, and the quantitative assay of GSH/GSSG, MDA, NAD
resultsHyperlipidemia disrupted osseointegration via downregulating the osteogenesis-related ROS/Wnt/β-catenin pathway and simultaneously upregulating the osteoclasis-related ROS/RANKL/NF-κB pathway. NAC application alleviated endoplasmic reticulum stress and mitochondrial dysfunction but failed to reduce lipid droplet accumulation. The intracellular oxidative damage is positively correlated with the accumulation of lipid droplets induced by hyperlipidemia.
conclusionLipid droplet accumulation is the primary cause for inducing oxidative damage, disturbing osteogenesis-osteoclasis balance, and impairing osseointegration in hyperlipidemia. This study highlights that reducing lipid droplet accumulation may serve as a potential strategy to enhance Ti implant osseointegration in hyperlipidemia.
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