ArticleBMC pregnancy and childbirth2025
Common sleep characteristics and the risk of common perinatal complications and adverse outcomes: a multi-sample, bidirectional Mendelian randomization study.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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Abstract
backgroundImproving maternal and child health has been a global priority since the early 2000s, with a focus on reducing perinatal complications and improving overall maternal well-being. Sleep characteristics influence various health outcomes, yet their role in perinatal complications and adverse outcomes remains poorly understood.
methodsA Mendelian randomization analysis was conducted, using seven common sleep characteristics (sleeplessness, sleep duration, getting up in the morning, daytime napping, morning/evening person, narcolepsy, snoring) as exposure factors and twelve common perinatal complications and adverse outcomes (preterm birth, polyhydramnios, slow fetal growth and fetal malnutrition, dystocia, umbilical cord-related complications, postpartum hemorrhage, fetal distress, gestational diabetes, pregnancy hypertension, eclampsia, abruptio placentae, placenta previa) as outcomes. A two-sample Mendelian randomization analysis was performed to infer causal effects.
resultsThe inverse variance weighted (IVW) analysis showed that sleeplessness was associated with preterm birth, sleep duration with gestational diabetes, and narcolepsy with pregnancy hypertension and eclampsia. These results were consistently supported by other methods, suggesting that sleep characteristics are causal risk factors for perinatal complications and adverse outcomes.
conclusionThis study found that sleeplessness is associated with preterm birth, sleep duration with gestational diabetes, and narcolepsy with pregnancy hypertension and eclampsia. These findings contribute to a better understanding of the impact of sleep characteristics on common perinatal complications and adverse outcomes. Targeting sleep interventions, such as improving sleep duration and addressing sleep disorders like sleeplessness and narcolepsy, may reduce the incidence of preterm birth, gestational diabetes, and pregnancy hypertension, offering effective strategies to improve maternal and infant health outcomes.
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