ArticleBMC cardiovascular disorders2025
The association between circulating palmitic acid levels and risk of premature coronary artery disease in Chinese patients: a case-control study.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- An Exploratory Field Study on Egg Quality and Yolk Functional Properties in Commercial and Local Laying Hen Breeds Fed Whole Hemp Seed Under Agroecological Conditions.Foods (Basel, Switzerland) · 2026Article
- Serum free eicosapentaenoic acid-to-arachidonic acid ratio and long-term risk of major adverse cardiovascular events in patients with coronary artery disease.Frontiers in cardiovascular medicine · 2026Article
- Multiple Roles of Palmitic Acid in Cardiovascular Diseases.Journal of inflammation research · 2025Review
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Authors and funding
13 authors.
Funding
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Abstract
backgroundPalmitic acid (PA) is a risk factor for atherosclerosis but its significance in premature coronary artery disease (PCAD) remains poorly understood. Herein, we investigated the impact of circulating PA levels on the risk of PCAD occurrence in Chinese patients.
methodsIn this case control study, we included patients diagnosed with PCAD and age-matched non-CAD controls between June 2022 and December 2023. Participants' serum PA levels were quantified using ultra-performance liquid chromatography-mass spectrometry, and correlations with PCAD were determined using R (v4.2.2). The potential mediating effect of low density lipoprotein cholesterol (LDL-C) for the association between PA and PACD was also evaluated.
resultsIn this study of 393 adults (206 PCAD patients and 187 non-CAD controls), serum PA levels showed significant positive correlations with LDL-C and total cholesterol. Compared to controls, PCAD patients had higher proportions of males, smokers, and diabetics, along with elevated PA, LDL-C, and triglycerides, but reduced HDL-C (all P < 0.05). Elevated serum PA (per 10µmol/L increase, OR = 1.12, 95% CI = 1.05-1.20) was significantly associated with an increased risk of PCAD after adjustment for multivariable factors. Further adjustment for LDL-C levels attenuated, but remained statistically significant, the association between PA and PCAD (per 10µmol/L increase, OR = 1.10, 95% CI = 1.03-1.18). Mediation analysis showed that LDL-C mediated 16% of PA's total effect on PCAD.
conclusionsElevated PA circulating levels were found to be related with PCAD risks among Chinese, and increased LDL-C levels could partly mediate this effect.
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