Evidence map›Paper›PMID 40437336›Full record

ArticleAnnals of surgical oncology2025

Integrating Magnetic Resonance Chemical Shift Imaging for Localized Prostate Cancer Risk Stratification on the Basis of the Impact of Periprostatic Brown Adipocytes Within Tumor Microenvironment.

Chih-Yu Shen, Jhih-Kai Pan, Wen-Der Lin, Hui-Chuan Cheng, Che-Yuan Hu, Kuan-Yu Wu, Yung-Ming Kuo, Gia-Shing Shieh, Pei-Jung Lu

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Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chih-Yu ShenInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Jhih-Kai PanInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wen-Der LinInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Hui-Chuan ChengInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Che-Yuan HuDepartment of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Kuan-Yu WuDepartment of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yung-Ming KuoDepartment of Electronic Engineering, College of Electrical and Computer of Engineering, National Formosa University, Tainan, Taiwan.
Gia-Shing ShiehDepartment of Urology, Tainan Hospital, Ministry of Health and Welfare, Tainan, Taiwan.
Pei-Jung LuInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. pjlu2190@mail.ncku.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe sought to characterize periprostatic adipose tissue (PPAT) with magnetic resonance imaging (MRI) featuring water-to-oil ratio (R PATIENTS AND

methodsBetween November 2021 and September 2023, 21 localized patients with prostate cancer were studied, categorized as low (n = 4), intermediate (n = 4), and high risk (n = 13). We utilized MRI to analyze the water-only signal and fat-only signal. R

resultsWe found significantly higher periprostatic adipose tissue R

conclusionsIn the study, the chemical shift image of MRI in 21 localized patients with prostate cancer revealed higher periprostatic adipose tissue water-to-oil ratio among patients with high-risk prostate cancer. Adipokines within the tumor-microenvironment attribute to the cancer aggressiveness, and targeting the fat fraction signal in MRI could improve the current risk stratification strategy.

Indexed as

Adipocytes, BrownMagnetic Resonance ImagingProstatic NeoplasmsTumor MicroenvironmentAgedHumansMaleMiddle AgedPrognosisRisk AssessmentBrown adipocyteMagnetic resonance imagingPeriprostatic adipose tissueProstate cancerRisk stratification

Identifiers

PMID40437336
PMCPMC12317911

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.