ArticleCommunications medicine2025
Natural killer cells adopt an activated and decidual-like phenotype after autologous hematopoietic stem cell transplantation in children with cancer.
Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Dynamics of NK cell subsets following autologous hematopoietic stem cell transplantation in adult oncologic patients.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
backgroundNatural killer (NK) cells are among the first immune cell populations to recover after autologous hematopoietic stem cell transplantation (autoHSCT ), yet their dynamic function in pediatric patients remains understudied. Investigating NK cell recovery could improve understanding of post-autoHSCT immune reconstitution and optimize clinical outcomes.
methodsWe characterized NK cells in 13 children (male: 8; female: 5; age range: 3-11 years) with various tumors before and up to 6 months after autoHSCT. Multiparametric flow cytometry analyses and plasma cytokine level determinations were performed. In vitro experiments, including single-cell RNA sequencing, were conducted to elucidate post-autoHSCT changes in the NK cell repertoire using 8 adult healthy donors (male: 5; female: 3; age range: 25-62 years).
resultsKey findings highlight a transient decidual-like NK cell phenotype emerging early post-transplant. These cells are immature and activated, with increased inhibitory receptor expression and diminished activating receptor levels. This activated and decidual-like phenotype is characterized by elevated expression of CD56, CD9, CD49a, CD151, CD38, HLA-DR, and CD55. Plasma levels of several cytokines are associated with the observed changes in NK cells' phenotype. In addition, in vitro experiments recapitulate the alterations observed in NK cells shortly after autoHSCT. Specifically, results demonstrate that the combination of IL-15 and TGF-β induces this distinctive phenotype on NK cells after autoHSCT. Finally, we observe a positive correlation between relapse and the percentage of CD56
conclusionsAltogether, our findings provide valuable insights into the physiopathology of NK cells during immune system reconstitution after autoHSCT and can potentially help in the management of cancer in children.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.