Evidence map›Paper›PMID 40437207›Full record

ArticleDocumenta ophthalmologica. Advances in ophthalmology2025

Visual pathway function in adults born preterm with very low birth weight: a two-country birth cohort study.

Anna P M Jørgensen, Maarit Kulmala, Dordi Austeng, Trond Sand, Arnstein Grøtting, Kari Anne I Evensen, Eero Kajantie, Anna Majander, Tora Sund Morken

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Documenta ophthalmologica. Advances in ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Anna P M JørgensenDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway. anna.p.m.jorgensen@ntnu.no.ORCID 0009-0000-2260-7303
Maarit KulmalaWelfare Epidemiology and Monitoring Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Dordi AustengDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway.
Trond SandDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway.
Arnstein GrøttingDepartment of Neurology and Clinical Neurophysiology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Kari Anne I EvensenDepartment of Clinical and Molecular Medicine, NTNU, Trondheim, Norway.
Eero KajantieWelfare Epidemiology and Monitoring Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Anna MajanderDepartment of Ophthalmology, Helsinki University Hospital, Helsinki, Finland.
Tora Sund MorkenDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway.

Funding

Research Council of Norway (RCN) 33405the European Commission RECAP Research on Children and Adults Born Preterm 733280
6 · The paper itself

Abstract

purposeTo investigate if preterm birth with very low birth weight (VLBW; birth weight < 1500 g) affects macular and visual pathway function in an adult population and explore if best corrected visual acuity (BCVA) was associated with any of the electrophysiologic responses.

methodsFifty participants born preterm with VLBW and 77 term-born controls years were recruited when aged 31-41 years from the Helsinki Study of Very Low Birth Weight Adults (Finland) and the NTNU Low Birth Weight Life study (Norway) studies. Pattern reversal electroretinogram (PR-ERG), visual evoked potential (PR-VEP) and BCVA were examined. PR-ERG components (P50, N95 peak time, amplitude and N95:P50 amplitude ratio) and PR-VEP components (N75, P100 and N145 peak time and amplitude) in the better-seeing eye were compared between the groups, and association with BCVA was examined.

resultsThe VLBW group showed longer N145 peak time compared to the control group (mean difference 6.8 ms, CI 2.0 to 11.5, p = 0.006) and lower N95:P50 amplitude ratio (CI - 0.3 to - 0.1, p = 0.003). Otherwise, both groups showed similar electrophysiological waveforms. No relationship was found between electrophysiologic responses and BCVA. BCVA was normal in birth groups and showed no group difference.

conclusionThe responses in the primary visual cortex (N75 and P100) to visual stimuli presented to the better-seeing eye were similar in adults born preterm with VLBW and term-born controls. However, in the VLBW group, there was an indication that subtle electrophysiological deviation may exist at a higher cortical level (N145) and in the ganglion cell response in the macula. These significant differences were not related to reduced visual acuity.

Indexed as

Evoked Potentials, VisualInfant, PrematureInfant, Very Low Birth WeightPremature BirthVisual AcuityVisual PathwaysAdultElectroretinographyFemaleFinlandGestational AgeHumansInfant, NewbornMaleNorwayAdultPattern reversal electroretinogramPattern reversal visual evoked potentialPretermVery low birth weight

Identifiers

PMID40437207
PMCPMC12334524

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.