ArticleNature computational science2025
A computational approach to evaluate how molecular mechanisms impact large-scale brain activity.
Article in Nature computational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Comprehensive profiling of brain dynamics during anesthesia across phylogeny.Nature neuroscience · 2026Article
- Spatially structured heterogeneity shapes large-scale cortical dynamics in a model of the human cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A spatially discretized convolutional neural mass model for studying meso-scale spatio-temporal transformations in the rat hippocampus.Research square · 2026Article
- Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains.Nature human behaviour · 2026Article
- Emergent multiscale organisation of neural dynamics fragments in anaesthesia.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms.eLife · 2025Article
- A computational approach to evaluate how molecular mechanisms impact large-scale brain activity.Nature computational science · 2025Article
- Entropy and Complexity Tools Across Scales in Neuroscience: A Review.Entropy (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Assessing the impact of pharmaceutical compounds on brain activity is a critical issue in contemporary neuroscience. Currently, no systematic approach exists for evaluating these effects in whole-brain models, which typically focus on macroscopic phenomena, while pharmaceutical interventions operate at the molecular scale. Here we address this issue by presenting a computational approach for brain simulations using biophysically grounded mean-field models that integrate membrane conductances and synaptic receptors, showcased in the example of anesthesia. We show that anesthetics targeting GABA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.