Evidence map›Paper›PMID 40437138›Full record

ArticleJournal of general internal medicine2025

Reduction in the Concomitant Ordering of Erythrocyte Sedimentation Rate and C-Reactive Protein Within a Large Academic Medical Center.

Ruchi Desai, Ray Zhang, Nainesh Shah, Maria Bacalao, Haidy Galous, David R Karp, Puneet Bajaj

Abstract read
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Article in Journal of general internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruchi DesaiDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA. ruchi.desai@utsouthwestern.edu.ORCID http://orcid.org/0000-0002-0720-8416
Ray ZhangDepartment of Pathology, UT Southwestern Medical Center, Dallas, TX, USA.
Nainesh ShahDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Maria BacalaoRheumatic Diseases Division, University of Texas Southwestern Medical Center, 2001 Inwood Rd, Dallas, TX, 75390-8887, USA.
Haidy GalousRheumatic Diseases Division, University of Texas Southwestern Medical Center, 2001 Inwood Rd, Dallas, TX, 75390-8887, USA.
David R KarpRheumatic Diseases Division, University of Texas Southwestern Medical Center, 2001 Inwood Rd, Dallas, TX, 75390-8887, USA.
Puneet BajajRheumatic Diseases Division, University of Texas Southwestern Medical Center, 2001 Inwood Rd, Dallas, TX, 75390-8887, USA. puneet.bajaj@utsouthwestern.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundErythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are two laboratory tests often ordered simultaneously to assess for inflammation. Studies show that CRP is superior to ESR, and co-ordering ESR and CRP increases expenditures and phlebotomy without demonstrable patient benefit.

objectiveOur quality improvement project aimed to reduce ESR/CRP co-ordering and total ESR orders in a safety-net health setting (health system 1) and a university setting (health system 2) within an academic medical center. DESIGN/

interventionsUsing plan, do, study, act (PDSA) methodology, we developed education and electronic health record (EHR) interventions, which included education to all rheumatology providers, targeted education to rheumatology providers with the highest ESR/CRP co-orders, removal of ESR from the rheumatology order set at health system 2, and implementation of a non-intrusive clinical decision support (CDS) change at both hospitals. MAIN MEASURES: We compared ESR/CRP co-orders, ESR-only orders, and CRP-only orders between pre- and post-intervention periods, as well as weekly average orders per 1000 patient days in the inpatient setting and per 1000 patient encounters in the outpatient setting and rheumatology clinics. KEY

resultsIn health system 1, average weekly ESR/CRP co-orders decreased by 25%, ESR-only orders decreased by 26%, and CRP-only orders increased by 11%. In health system 2, average weekly ESR/CRP co-orders decreased by 36%, ESR-only orders decreased by 47%, and CRP-only orders increased by 65%. Most of the change was seen in the outpatient setting, with >80% reduction in ESR/CRP co-ordering by the rheumatology division in both health systems. Using ESR and CRP Medicare reimbursement rates, estimated payer savings system-wide were $59,354.33 over 1 year.

conclusionSpecialty-led and targeted educational interventions and non-intrusive simple EHR CDS changes are effective in reducing redundant laboratory testing to provide higher value care.

Indexed as

Choosing Wisely CampaignClinical decision supportCRPESROrdering practices

Identifiers

PMID40437138

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.