ArticleScientific reports2025
Formulation of pH responsive polymeric hydrogels for prolonged delivery of famciclovir with biosafety evaluation.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- QbD aided optimization and molecular docking of pH-sensitive hydrogels for targeted colon delivery in ulcerative colitis.RSC advances · 2026Article
- Alkaline-Enhanced Poly(Acrylic Acid)/Sodium Alginate/PEO Hydrogels: Structural Modifications and Functional Properties for Agriculture.Gels (Basel, Switzerland) · 2026Article
- A dual-function rebamipide cubogel for enhanced ocular penetration and tear film restoration: optimization, safety, and in-vivo evaluation.Drug delivery and translational research · 2026Article
- Advanced Biocompatible and Biodegradable Polymers: A Review of Functionalization, Smart Systems, and Sustainable Applications.Polymers · 2025Review
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Authors and funding
10 authors.
Funding
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Abstract
Recent study aimed to fabricate pH responsive, intelligent, Pluronic F127 based polymeric system for controlled delivery of Famciclovir. Nine formulations were developed through free radical polymerization. Polymeric system exhibited pH dependent swelling by showing higher degree of swelling in simulated intestinal fluid of pH 7.4 while negligible swelling in simulated gastric fluid of pH 1.2. Drug loading increased with increase in percent water content. Famciclovir loading percent was found in range of 60.892% to 73.741%. In FTIR spectra, characteristic peaks were achieved confirming the successful grafting of drug in polymeric system. PXRD results demonstrated the conversion of crystalline nature of Famciclovir into an amorphous one in the loaded hydrogel. SEM confirmed the porous nature of hydrogel. Famciclovir loaded hydrogel showed superior thermal behavior as compared to the drug alone. In vitro Famciclovir release studies unveiled small quantity of drug release in simulated gastric fluid (25.55-34.89%) while maximal release in simulated intestinal fluid (90.12-99.13%) for 36 h was documented thereby confirming pH regulated release. Application of DD solver revealed that PLMA hydrogels followed zero order while First order was being followed by Famciclovir marketed tablet. No toxicity signs were observed in rabbits establishing the biosafety of system. Hence, the results suggest that Pluronic based polymeric system can act as promising carrier for controlled, site specific delivery of Famciclovir in intestine for prolonged period thereby reducing its dosing frequency and minimizing gastric side effects for treating Herpes and Varicella zoster infections.
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