ArticleNature2025
The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- [Recent Advances in the Interorgan Regulatory Roles of Adipose Tissue].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Pooled it
- The Impact of Antigen Presentation on BBB Disruption and Neuroinflammation.Physiology (Bethesda, Md.) · 2026Review
- The effects of IFNγ on tissue physiology through structural cells.Nature reviews. Immunology · 2026Review
- Article
- Intestinal infections establish antigen-specific, long-lived memory CD4Nature neuroscience · 2026Article
- Antigen presentation by CD40Nature · 2026Article
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- Gut-brain-immune interactions in neonatal hypoxic-ischemic brain injury.Molecular and cellular pediatrics · 2026Review
- A novel interoceptive subfornical organ to infralimbic cortex mechanism relays airway inflammation effects on fear extinction.Journal of neuroinflammation · 2026Article
- Living rent free in your head: resident memory T cells.ImmunoHorizons · 2026Review
- Simulated spaceflight disrupts the immune-gut-brain axis and drives sex-dependent neuroinflammation, axonal injury, and behavioral deficits.bioRxiv : the preprint server for biology · 2026Article
- Neuroimmune regulation of behavior: Focus on sensory circumventricular organs and associated cell circuit mechanisms.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Microglia alter autonomic nucleus neuronal activation after peripheral cytokine challenge.American journal of physiology. Cell physiology · 2026Article
- Article
- Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility.Cell systems · 2026Article
- Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition.Immunity · 2026Article
- Nested ecosystems theory for conceptualizing brain tumors.Disease models & mechanisms · 2026Review
- Pushing the frontier of gut microbiome health cross-kingdom and cross-organ.Nature reviews. Gastroenterology & hepatology · 2026Article
- Changes in peripheral immune cell phenotypes and their roles in autism: insights from clinical and animal model studies.Molecular psychiatry · 2026Review
- A single-cell atlas of intestinal immune cells across the day-night cycle reveals dynamic populations.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Tomomi M YoshidaDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-4529-720X
Mytien NguyenDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7343-6882
Le ZhangDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Benjamin Y LuDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8764-8384
Biqing ZhuProgram of Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.ORCID 0000-0002-7428-6297
Katie N MurrayDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Yann S MineurDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Cuiling ZhangDepartment of Rheumatology, Allergy and Immunology, Yale School of Medicine, New Haven, CT, USA.
Di XuDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Elizabeth LinDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Joseph LuchsingerDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Sagar BhattaDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Daniel A WaizmanDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-3690-7793
Mackenzie E CodenDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Yifan MaDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Kavita Israni-WingerDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Anthony RussoDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0623-6618
Haowei WangDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Wenzhi SongDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Jafar Al SouzDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2345-2803
Hongyu ZhaoProgram of Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.ORCID 0000-0003-1195-9607
Joseph E CraftDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1368-6756
Marina R PicciottoDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4404-1280
Jaime GrutzendlerDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-5000-243X
Marcello DistasioDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Noah W PalmDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7262-9455
David A HaflerDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA. david.hafler@yale.edu.ORCID 0000-0003-4664-535X
Andrew WangDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA. andrew.wang@yale.edu.ORCID 0000-0002-6951-8081
Funding
Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI Eric P. Winer · 1985 to 2026
$85.0MRole of Negative Costimulation in Regulation of AutoimmunityP01AI039671 · NIAID · YALE UNIVERSITY · PI VIJAY K. KUCHROO · 1996 to 2026
$51.7MYale SPORE in Skin CancerP50CA121974 · NCI · YALE UNIVERSITY · PI MARCUS W BOSENBERG, Harriet M. Kluger · 2006 to 2026
$43.9MTransgenic / Knock-out mouse coreP01AI073748 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI HAFLER, DAVID A. · 2008 to 2019
$17.1MINTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007019 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, David G. Schatz · 1985 to 2026
$14.4MIMMUNE RESPONSES IN LUPUSR37AR040072 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2000 to 2025
$7.4MRESEARCH TRAINING - BIOLOGICAL SCIENCEST32MH014276 · NIMH · YALE UNIVERSITY · PI Marina R Picciotto · 1985 to 2026
$7.2MAcetylcholine signaling allows cognitive processes in the brain to regulate physiological responses to the environment: the example of central control of opiate toleranceDP1DA050986 · NIDA · YALE UNIVERSITY · PI PICCIOTTO, MARINA R · 2019 to 2023
$5.9MDissecting How Xenobiotics Act as Adjuvants for Oral Allergic SensitizationR01AI162645 · NIAID · YALE UNIVERSITY · PI Andrew Wang · 2021 to 2026
$3.6M(8) Mechanisms of autoimmune endocrine diseases in patients receiving checkpoint inhibitorsR01CA227473 · NCI · YALE UNIVERSITY · PI HEROLD, KEVAN C, KLUGER, HARRIET M. · 2018 to 2022
$3.2MThe Role of the Adrb3/IL6 Axis in the Impact of Psychosocial Stress on Lupus PathogenesisR01AR080104 · NIAMS · YALE UNIVERSITY · PI Andrew Wang · 2022 to 2026
$2.2MHigh Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2MNCI NIH HHS P30 CA016359NCI NIH HHS P50 CA121974NCI NIH HHS R01 CA227473NEI NIH HHS K08 EY033013NIAID NIH HHS P01 AI039671NIAID NIH HHS P01 AI073748NIAID NIH HHS R01 AI162645NIAID NIH HHS T32 AI007019NIAMS NIH HHS R01 AR080104NIAMS NIH HHS R37 AR040072NIDA NIH HHS DP1 DA050986NIH HHS S10 OD026996NIH HHS S10 OD030363NIMH NIH HHS T32 MH014276NINDS NIH HHS F31 NS130957
Abstract
Specialized immune cells that reside in tissues orchestrate diverse biological functions by communicating with parenchymal cells
Indexed as
CD4-Positive T-LymphocytesSubfornical OrganAdaptive ImmunityAdipose TissueAnimalsBrain-Gut AxisFemaleGastrointestinal MicrobiomeHomeostasisHumansInterferon-gammaMaleMeningesMiceMice, Inbred C57BLReceptors, CXCR6Interferon-gammaReceptors, CXCR6
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.