ArticleNature2025
CoQ imbalance drives reverse electron transport to disrupt liver metabolism.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Mitochondria limit coenzyme Q export under cholesterol biosynthetic stress.The Journal of cell biology · 2026Article
- Dietary Green Alfalfa Supplementation Reduces Backfat Thickness and Improves Muscle Water-Holding Capacity in Diqing Tibetan Pigs.Foods (Basel, Switzerland) · 2026Article
- Metabolic Crosstalk Between Host and Tumor as a Circuit of Resilience in Cancer Therapy.Cells · 2026Review
- Article
- From Lipids to Mitochondria: Shared Metabolic Alterations in Obesity and Alzheimer's Disease.Cells · 2026Review
- Metabolic advances in 2025: from clinical breakthroughs to molecular reprogramming.Metabolism open · 2026Article
- MLKL in liver parenchymal cells promotes liver cancer in murine metabolic dysfunction-associated steatotic liver disease.Cell death & disease · 2026Article
- A clickable CoQ imaging probe reveals that cellular uptake and lysosomal trafficking depend on CD36 and NPC1.Redox biology · 2026Article
- Membrane Stress and Ferroptosis: Lipid Dynamics in Cancer.International journal of molecular sciences · 2026Review
- The unified cardiometabolic disease continuum: mechanistic stages of a single pathophysiological process.Frontiers in endocrinology · 2026Review
- Mitochondrial Dysfunction in Type 2 Diabetes and Metabolic Syndrome: Mechanisms, Biomarkers, and Emerging Therapies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Uptake mechanisms and functions of isolated mitochondria in mesenchymal stromal cells.Scientific reports · 2025Article
- Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology.Nature metabolism · 2025Article
- Obesity-Driven Metabolic Disorders: The Interplay of Inflammation and Mitochondrial Dysfunction.International journal of molecular sciences · 2025Review
- Atorvastatin Induces Bioenergetic Impairment and Oxidative Stress Through Reverse Electron Transport.Antioxidants (Basel, Switzerland) · 2025Article
- Respiratory complex IIIbioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Renata L S GoncalvesDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Zeqiu Branden WangDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Jillian K RiverosDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.ORCID 0009-0008-0964-2620
Güneş ParlakgülDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0001-9365-7287
Karen E InouyeDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0003-2743-2121
Grace Yankun LeeDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Xiaorong FuCenter for Human Nutrition and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-8042-4206
Jani SaksiDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Clement RosiqueDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Sheng Tony HuiDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Mar CollFundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CiberEHD), Barcelona, Spain.ORCID 0000-0003-3726-0087
Ana Paula ArrudaDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0001-6179-2687
Shawn C BurgessCenter for Human Nutrition and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-9586-5511
Isabel GrauperaDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Gökhan S HotamışlıgilDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA. ghotamis@hsph.harvard.edu.ORCID 0000-0003-2906-1897
Funding
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff G McDonald · 2022 to 2026
$7.4MFactors controlling metabolic flux in the liver - Supplement RevisionR01DK078184 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Shawn C Burgess · 2008 to 2026
$6.8MNovel pathways controlling macrophage inflammation and resolution in atherosclerosisR01HL148137 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI HOTAMISLIGIL, GOKHAN S · 2019 to 2022
$2.9MRegulation of lipogenesis by TCA cycle metabolismR01DK128168 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BURGESS, SHAWN C · 2021 to 2025
$2.1MRole of Adipokine FABP4 in Glucoregulation and Counter Regulatory ResponsesR01DK123458 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI HOTAMISLIGIL, GOKHAN S · 2020 to 2023
$2.0MNHLBI NIH HHS R01 HL148137NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK078184NIDDK NIH HHS R01 DK123458NIDDK NIH HHS R01 DK128168
Abstract
Mitochondrial reactive oxygen species (mROS) are central to physiology
Indexed as
LiverUbiquinoneAnimalsElectron TransportElectron Transport Complex IFatty LiverFemaleHumansMaleMiceMice, Inbred C57BLObesityReactive Oxygen SpeciesElectron Transport Complex IReactive Oxygen SpeciesUbiquinone
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.