ArticleNature2025
Preoptic EP3R neurons constitute a two-way switch for fever and torpor.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
–field-weighted citation impact
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Who cites it
12 citing papers in PubMed.
- Neurobehavioral Consequences of the 5'-AMP-Induced Torpor-like Hypothermic State.Life (Basel, Switzerland) · 2026Article
- Delta-Band Dynamics of CaMKI-Positive Preoptic Neurons Encode Thermal Homeostatic Information.Neuroscience bulletin · 2026Article
- Neurokinin receptor antagonists for vasomotor symptoms: from KNDy neurons to clinical translation.Nature reviews. Endocrinology · 2026Review
- Neural Control of Homeothermy, Torpor, and Hibernation.Annual review of neuroscience · 2026Review
- Neural circuits of torpor.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Article
- A Preoptic Neuronal Population Regulates Energy Expenditure and Balance.bioRxiv : the preprint server for biology · 2026Article
- Inhibition of daily torpor in mice requires calories, not just feeding: a potential role for GLP-1.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Brain-immune interactions generate pathogen-specific sickness states.bioRxiv : the preprint server for biology · 2025Article
- Artificially induced torpor during pregnancy impairs fetal growth in mice.Scientific reports · 2025Article
- Hypothalamic prolactin signaling protects against overheating in pregnancy.Trends in neurosciences · 2025Article
- Melanocortin-responsive Kiss1 neurons of the arcuate nucleus drive energy expenditure through glutamatergic signaling to the dorsomedial hypothalamus.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Update of
Authors and funding
14 authors.
Natalia L S MachadoDepartment of Neurology, Beth Israel Deaconess Medical Center and Division of Sleep Medicine and Program in Neuroscience, Harvard Medical School, Boston, MA, USA. nmachado@bidmc.harvard.edu.ORCID 0000-0001-8750-2676
Nicole LynchDepartment of Neurology, Beth Israel Deaconess Medical Center and Division of Sleep Medicine and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
Luis H A CostaDepartment of Neurology, Beth Israel Deaconess Medical Center and Division of Sleep Medicine and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
David MelvilleDepartment of Neurology, Beth Israel Deaconess Medical Center and Division of Sleep Medicine and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
Hakan KucukdereliDivision of Endocrinology, Metabolism and Diabetes, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Satvinder KaurDepartment of Neurology, Beth Israel Deaconess Medical Center and Division of Sleep Medicine and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8243-2880
Alexander S BanksDivision of Endocrinology, Metabolism and Diabetes, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1787-6925
Francesca RaffinDepartment of Neurology, Beth Israel Deaconess Medical Center and Division of Sleep Medicine and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.ORCID 0009-0000-8169-0450
Oscar D Ramirez-PlascenciaDepartment of Neurology, Beth Israel Deaconess Medical Center and Division of Sleep Medicine and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6862-4974
Sydney AtenDepartment of Neurology, Beth Israel Deaconess Medical Center and Division of Sleep Medicine and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
Janayna D LimaDepartment of Neurology, Beth Israel Deaconess Medical Center and Division of Sleep Medicine and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
Sathyajit S BandaruDepartment of Neurology, Beth Israel Deaconess Medical Center and Division of Sleep Medicine and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
Richard D PalmiterHoward Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6587-0582
Clifford B SaperDepartment of Neurology, Beth Israel Deaconess Medical Center and Division of Sleep Medicine and Program in Neuroscience, Harvard Medical School, Boston, MA, USA. csaper@bidmc.harvard.edu.ORCID 0000-0002-5788-3014
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6MWakefulness and Forebrain Activation by Orexin NeuronsP01HL095491 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLMAN, DAVID ANDREW · 2010 to 2019
$25.1MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0MCircuitry for Circadian RhythmsR01NS072337 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAPER, CLIFFORD B · 2010 to 2023
$4.8MHypothalamic arousal systemsR01NS085477 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAPER, CLIFFORD B · 2014 to 2018
$2.8MDissection of the Circuitry Regulating Arousal to PainR01NS112175 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAUR, SATVINDER · 2019 to 2023
$1.9MInstrumentation for Noninvasive Measurement of Glucose and Energy Balance in Mice with Continuous Glucose Telemetry and Indirect CalorimetryS10OD028635 · OD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BANKS, ALEXANDER · 2020 to 2020
$737kNHLBI NIH HHS P01 HL095491NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK046200NIH HHS S10 OD028635NINDS NIH HHS R01 NS072337NINDS NIH HHS R01 NS085477NINDS NIH HHS R01 NS112175
Abstract
Many species use a temporary decrease in body temperature and metabolic rate (torpor) as a strategy to survive food scarcity in a cool environment. Torpor is caused by preoptic neurons that express a variety of peptides and receptors
Indexed as
FeverNeuronsPreoptic AreaReceptors, Prostaglandin E, EP3 SubtypeTorporAnimalsBody TemperatureCalciumCyclic AMPFemaleLipopolysaccharidesMaleMiceOptogeneticsCalciumCyclic AMPLipopolysaccharidesReceptors, Prostaglandin E, EP3 Subtype
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.