ArticleScientific reports2025
Experimental analysis of metamaterial integrated applicator for hyperthermia cancer treatment.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Metamaterial-Assisted Miniaturized Antennas for Targeted Microwave Hyperthermia: From Deep Tissue Focus to Energy Efficiency.Annals of biomedical engineering · 2026Review
- Microwave technologies for biomedical diagnosis and therapy: advances, challenges, and perspectives.Mikrochimica acta · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A metamaterial integrated applicator operating at 2.45 GHz has been developed for focused heating in clinical hyperthermia applications, effectively heating tumors while minimizing surface hot spots. This innovative applicator combines a double spiral antenna (DSA) for energy delivery, a spiral frequency selective surface (SFSS) for focused energy distribution, and an artificial magnetic conductor (AMC) as a reflector to enhance penetration and uniformity. To ensure durability and environmental protection, the entire structure, including the DSA, SFSS, and AMC, is encased in a Teflon layer. The applicator's performance is evaluated using heterogeneous phantoms, the Gustav Voxel model, and head tissue-simulating liquid, replicating real-world conditions. Its thermal efficiency is further analyzed with a water bolus that includes a 1 mm polyvinyl chloride (PVC) layer to safeguard superficial tissues and enable uniform heat distribution. The applicator achieves a therapeutic temperature of 44 °C in tumors with just 3 W of input power, demonstrating exceptional efficiency. Impedance matching and resonance at 2.45 GHz ensure effective energy delivery to target tissues. Specific absorption rate (SAR) measurements at 0.1 W input confirm consistent energy distribution across varying depths. The strong alignment between simulation and experimental results validates the applicator's design, making it a reliable and precise tool for hyperthermia therapy.
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Registered trials
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