Utility of unique optical properties of Anethum graveolens green synthesized mediated-alumina nanoparticles for spectrofluorometric determination of darifenacin in pharmaceutical products.

Seham S Alterary, Gamal A E Mostafa, Maha F El-Tohamy, Haitham AlRabiah

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Seham S AlteraryDepartment of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh, 11495, Saudi Arabia.

Gamal A E MostafaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia. gmostafa@ksu.edu.sa.

Maha F El-TohamyDepartment of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh, 11495, Saudi Arabia.

Haitham AlRabiahDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, a new fluorescence-based analytical method for the determination of darifenacin (DFN) in pharmaceutical formulations using alumina nanoparticles (NPs) and sodium dodecyl sulfate (SDS) is presented. The alumina NPs were synthesized by a green method using Anethum graveolens (extract as a reducing and stabilizing agent. The NPs were characterized by UV-vis spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR). The method enhanced the fluorescence of alumina NPs in the presence of SDS, which stabilized the particles and maintained their dispersion. DFN interacts with the NPs, enhancing fluorescence emission and allowing sensitive detection at λ

Indexed as

Aluminum OxideMetal NanoparticlesNanoparticlesGreen Chemistry TechnologyLimit of DetectionPharmaceutical PreparationsPlant ExtractsSpectrometry, FluorescenceSpectroscopy, Fourier Transform InfraredX-Ray DiffractionAluminum OxidePharmaceutical PreparationsPlant ExtractsAlumina nanoparticlesAnethum graveolensDarifenacinFluorescence systemGreen chemistry

Identifiers

PMID40437031

DOI10.1038/s41598-025-99677-3

PMCPMC12119892

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.