Evidence map›Paper›PMID 40437011›Full record

ArticleScientific reports2025

Use of PCR cycle threshold values for toxins A and B quantification in Clostridioides difficile infections.

Rebecca Smith-Aguasca, Nestor Camenforte, Lara Rodríguez, Sergio Herrera, Katariina Vara, Dietrich Lueerssen, Frederick van Deursen, Carla Camprubí-Font, Luis Peñarrubia, Oriol Vidal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rebecca Smith-AguascaBiology Department, Universitat de Girona, Girona, Spain. rebecca.smithaguasca@qiagen.com.
Nestor CamenforteSTAT-Dx Life S.L. (A QIAGEN company), Barcelona, Spain.
Lara RodríguezSTAT-Dx Life S.L. (A QIAGEN company), Barcelona, Spain.
Sergio HerreraSTAT-Dx Life S.L. (A QIAGEN company), Barcelona, Spain.
Katariina VaraSTAT-Dx Life S.L. (A QIAGEN company), Barcelona, Spain.
Dietrich LueerssenSTAT-Dx Life S.L. (A QIAGEN company), Barcelona, Spain.
Frederick van DeursenQIAGEN Manchester Ltd, Citylabs 2.0, Hathersage Road, Manchester, M13 0BH, UK.
Carla Camprubí-FontSTAT-Dx Life S.L. (A QIAGEN company), Barcelona, Spain.
Luis PeñarrubiaSTAT-Dx Life S.L. (A QIAGEN company), Barcelona, Spain.
Oriol VidalBiology Department, Universitat de Girona, Girona, Spain.

Funding

PhD program, funded by Generalitat de Catalunya 2023 DI 00044
6 · The paper itself

Abstract

Increasingly, tcdA/tcdB qPCR is being used to diagnose Clostridioides difficile infections (CDI). Under the hypothesis that toxin genes' quantification through Ct values could potentially improve clinical accuracy, this study aimed to assess the linearity of the C. difficile assay on the QIAstat-Dx

Indexed as

Bacterial ProteinsBacterial ToxinsClostridioides difficileClostridium InfectionsEnterotoxinsReal-Time Polymerase Chain ReactionHumansBacterial ProteinsBacterial ToxinsEnterotoxinstcdA protein, Clostridium difficiletoxB protein, Clostridium difficileBacterial loadClostridioides difficileCycle threshold valueQIAstat-DxSyndromic testingToxin

Identifiers

PMID40437011
PMCPMC12119821

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.