Evidence map›Paper›PMID 40436873›Full record

ArticleNPJ Parkinson's disease2025

Computer vision uncovers three fundamental dimensions of levodopa-responsive motor improvement in Parkinson's disease.

Florian Lange, Diego L Guarin, Esther Ademola, Dalia Mahdy, Gabriela Acevedo, Thorsten Odorfer, Joshua K Wong, Jens Volkmann, Robert Peach, Martin Reich

Abstract read
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Probabilistic mapping of tremor control and gait ataxia risk in deep brain stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Florian LangeDepartment of Neurology, University of Würzburg, Würzburg, Germany. Lange_L@ukw.de.
Diego L GuarinMovement Estimation and Analysis Laboratory, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
Esther AdemolaDepartment of Neurology, University of Würzburg, Würzburg, Germany.
Dalia MahdyDepartment of Neurology, University of Würzburg, Würzburg, Germany.
Gabriela AcevedoMovement Estimation and Analysis Laboratory, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
Thorsten OdorferDepartment of Neurology, University of Würzburg, Würzburg, Germany.
Joshua K WongFixel Institute for Neurological Disease, College of Medicine, University of Florida, Gainesville, FL, USA.
Jens VolkmannDepartment of Neurology, University of Würzburg, Würzburg, Germany.
Robert Peach *Department of Neurology, University of Würzburg, Würzburg, Germany.
Martin Reich *Department of Neurology, University of Würzburg, Würzburg, Germany.

Funding

Deutsche Forschungsgemeinschaft 424778381Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg Z-3BC/19
6 · The paper itself

Abstract

We developed VisionMD, an AI computer vision platform, analyzing over 1200 clinical videos of Parkinson's patients' hand movements across 13 years. This large-scale, markerless analysis identified three kinematic domains (speed, consistency, timing/scale) reliably improved by levodopa. Our method offers objective, quantitative motor assessment, reducing subjectivity and enhancing reproducibility compared to traditional scales.

Identifiers

PMID40436873
PMCPMC12119790

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.