ArticleNPJ biofilms and microbiomes2025
Mediation effect and metabolic pathways of gut microbiota in the associations between lifestyles and dyslipidemia.
Article in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mediterranean diet research trajectories in China (2006-2025): a scoping review and scientometric analysis to localize global nutrition models.Frontiers in nutrition · 2025Pooled it
- Specific gut microbes are associated with the incidence of cardiometabolic disease in the HELIUS cohort.NPJ biofilms and microbiomes · 2026Article
- Machine learning model integrating oral microbiota and clinical features for predicting osteoporosis and bone loss in high-altitude populations.BMC microbiology · 2026Article
- Disease-specific crosstalk of Alistipes with lipoprotein profiles in overweight individuals at high cardiometabolic risk.Scientific reports · 2026Article
- The Safety ofViruses · 2026Article
- Maternal cafeteria diet and methyl donor supplementation modulate gut microbiota and anxiety-like behavior in male offspring.Food & nutrition research · 2026Article
- Exercise prescription for mood and cognition: targeting the microbiota-gut-brain axis through short-chain fatty acids.Frontiers in microbiology · 2026Review
- Therapeutic Potential of Probiotics in Metabolic Dysfunction-Associated Steatohepatitis: A Comprehensive Review.Microorganisms · 2025Review
- Structural and functional characterization of gut microbiota in dyslipidemic patients from high-altitude Tibetan pastoral areas.Frontiers in nutrition · 2025Article
- Body mass index distinctly modulates the associations between Alistipes and CRP/IL-6 in metabolic and lupus inflammatory features.PloS one · 2025Article
- Gut microbiota-metabolome remodeling associated with low bone mass: an integrated multi-omics study in fracture patients.Frontiers in molecular biosciences · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Whether the role of gut microbial features lies in the pathways from lifestyles to dyslipidemia remains unclear. In this cross-sectional study, we conducted a metagenome-wide association analysis and fecal metabolomic profiling in 994 adults from the China Multi-Ethnic cohort. A total of 26 microbial species were identified as mediators between lifestyle factors and risk for dyslipidemia. Specifically, the abundance of [Ruminococcus] gnavus mediated the associations between lifestyles and risks for dyslipidemia, elevated low-density lipoprotein cholesterol, elevated total cholesterol, and elevated triglycerides. [Ruminococcus] gnavus, Alistipes shahii, and Lachnospira eligens were replicated to be associated with dyslipidemia in an external validation cohort. The potential metabolic pathways included arachidonic acid, bile acid, and aromatic amino-acid metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.