Evidence map›Paper›PMID 40436823›Full record

ArticleNature communications2025

WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity.

Alissa J Trzeciak, Zong-Lin Liu, Mohamed Gatie, Adam S Krebs, Waleska Saitz Rojas, Anya J O'Neal, Ann K Baako, Zhaoquan Wang, Justin Nelson, Isabella C Miranda and 14 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Alissa J TrzeciakImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. trzeciaa@mskcc.org.ORCID http://orcid.org/0000-0002-4518-0098
Zong-Lin LiuImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mohamed GatieDevelopmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA.ORCID http://orcid.org/0000-0001-8500-5609
Adam S KrebsImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Waleska Saitz RojasImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Anya J O'NealImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-5188-1344
Ann K BaakoDevelopmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA.
Zhaoquan WangImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-8227-0941
Justin NelsonLouis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Isabella C MirandaDivision of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA.
Jazib UddinJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.
Allie LipshutzImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-1786-7300
Jian XieDepartment of Medicine, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Chou-Long HuangDepartment of Medicine, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0001-9963-3040
Pedro H V SaavedraDepartment of Biology, Northeastern University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7659-4533
Anna-Katerina HadjantonakisLouis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michael OverholtzerLouis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-3007-4986
Michael S GlickmanImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-7918-5164
Arohan R SubramanyaDept of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Thomas VierbuchenLouis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5690-5680
Jon Iker Etchegaray *Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Christopher D Lucas *University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, BioQuarter, UK.ORCID http://orcid.org/0000-0002-7523-0295
Christopher N Parkhurst *Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA.
Justin S A PerryImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. perryj@mskcc.org.ORCID http://orcid.org/0000-0003-4063-6524

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
RESEARCH PROJECT 2U19AI135990 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2018 to 2026
$21.4M
Tumor-specific T cell state dynamics and heterogeneity in early tumorigenesisU54CA209975 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LESLIE, CHRISTINA S, RUDENSKY, ALEXANDER Y · 2016 to 2021
$11.8M
Resource Development CoreU54DK137329 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas R Kleyman · 2023 to 2026
$4.8M
Control of the Renal WNK Signaling Pathway by Phase TransitionsR01DK098145 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AYLIN RACHEL RODAN, AROHAN R SUBRAMANYA · 2014 to 2026
$4.2M
IMMUNOLOGY RESEARCH TRAININGT32CA009149 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI RUDENSKY, ALEXANDER Y · 1985 to 2022
$4.0M
WNK kinase cascade in health and diseaseR01DK111542 · NIDDK · UNIVERSITY OF IOWA · PI Chou-Long Huang · 2017 to 2026
$3.6M
Rethinking the "quiet" nature of apoptotic cell clearance.DP2GM146337 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI PERRY, JUSTIN S · 2021 to 2024
$2.6M
Microbial Regulation of Microglial FunctionK08MH130773 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI PARKHURST, CHRISTOPHER NEAL · 2022 to 2025
$782k
Regulation of tumor-associated phagocyte physiology during tumor cell clearanceR00CA237728 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PERRY, JUSTIN S · 2019 to 2021
$747k
WNK1-dependent macropinocytosis mediates emergency myelopoiesisK99HL171844 · NHLBI · SLOAN-KETTERING INST CAN RESEARCH · PI TRZECIAK, ALISSA JANE · 2024 to 2025
$251k
NCI NIH HHS P30 CA008748NCI NIH HHS R00 CA237728NCI NIH HHS T32 CA009149NCI NIH HHS U54 CA209975NHLBI NIH HHS K99 HL171844NIAID NIH HHS U19 AI135990NIDDK NIH HHS R01 DK098145NIDDK NIH HHS R01 DK111542NIDDK NIH HHS U54 DK137329NIGMS NIH HHS DP2 GM146337NIMH NIH HHS K08 MH130773Pew Charitable Trusts Research Scholars AwardRCUK | Medical Research Council (MRC) MR/W019264/1RCUK | Medical Research Council (MRC) MR/X019314/1U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1K99HL171844U.S. Department of Health & Human Services | National Institutes of Health (NIH) 5K08MH130773U.S. Department of Health & Human Services | National Institutes of Health (NIH) 5R00CA237728U.S. Department of Health & Human Services | National Institutes of Health (NIH) 5T32CA009149U.S. Department of Health & Human Services | National Institutes of Health (NIH) 5U54CA209975U.S. Department of Health & Human Services | National Institutes of Health (NIH) DK111542U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30CA008748U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01DK098145U.S. Department of Health & Human Services | National Institutes of Health (NIH) U54DK137329
6 · The paper itself

Abstract

Tissue-resident macrophages (TRM) are critical for mammalian organismal development and homeostasis. Here we report that with-no-lysine 1 (WNK1) controls myeloid progenitor fate, with Csf1r

Indexed as

Macrophage Colony-Stimulating FactorMacrophagesPinocytosisWNK Lysine-Deficient Protein Kinase 1AnimalsCell DifferentiationCell LineageHumansInterferon Regulatory Factor-8Interferon Regulatory FactorsMiceMice, Inbred C57BLMice, KnockoutMyeloid Progenitor CellsNeutrophilsInterferon Regulatory Factor-8Interferon Regulatory FactorsMacrophage Colony-Stimulating FactorWnk1 protein, mouseWNK Lysine-Deficient Protein Kinase 1

Identifiers

PMID40436823
PMCPMC12120055

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.