Evidence map›Paper›PMID 40436777›Full record

ArticleEndocrine journal2025

Effects of excessive iodine intake during the perinatal period on thyroid function and higher brain functions in mouse offspring.

Izuki Amano, Ayane Ninomiya, Hiroyuki Yajima, Machiko Suda-Yajima, Michifumi Kokubo, Miski Aghnia Khairinisa, Yusuke Takatsuru, Reika Kawabata-Iwakawa, Satomi Kameo, Shogo Haraguchi and 2 more

Abstract read
In one paragraph

Article in Endocrine journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Izuki AmanoDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.ORCID http://orcid.org/0000-0002-5076-2041
Ayane NinomiyaDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.ORCID http://orcid.org/0000-0001-5540-1459
Hiroyuki YajimaDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
Machiko Suda-YajimaDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
Michifumi KokuboDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
Miski Aghnia KhairinisaDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.ORCID http://orcid.org/0000-0002-4314-9273
Yusuke TakatsuruDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.ORCID http://orcid.org/0000-0002-2730-3402
Reika Kawabata-IwakawaDivision of Integrated Oncology Research, Initiative for Advanced Research, Gunma University, Gunma 371-8511, Japan.ORCID http://orcid.org/0000-0002-3504-1393
Satomi KameoDepartment of Nutrition, Koshien University, Hyogo 665-0006, Japan.
Shogo HaraguchiDepartment of Biochemistry, Showa University School of Medicine, Tokyo 142-0064, Japan.ORCID http://orcid.org/0000-0002-8731-3311
Asahi HaijimaDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
Noriyuki KoibuchiDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.ORCID http://orcid.org/0000-0002-2247-9740

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iodine is an essential trace element crucial for thyroid hormone synthesis. While iodine deficiency has been recognized as a global health concern due to its association with hypothyroidism, certain regions may face challenges related to excessive iodine intake. The impact of excessive iodine intake during the perinatal period on higher brain functions remains unclear. To address this gap, we conducted a study using an animal model to elucidate the effects of perinatal iodine excess on higher brain functions. Dams received specific drinking water (control, ×20 iodine (KIO

Indexed as

BrainIodinePrenatal Exposure Delayed EffectsThyroid GlandAnimalsAnimals, NewbornBehavior, AnimalFemaleHippocampusLearningMaleMemoryMicePregnancyIodineIodine excessLearningMemoryThyroid hormone

Identifiers

PMID40436777
PMCPMC12436078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.