Evidence map›Paper›PMID 40436643›Full record

ArticleJournal of Zhejiang University. Science. B2025

Metagenomics reveals an increased proportion of an

Jinyou Li, Yue Wu, Yichen Yang, Lufang Chen, Caihong He, Shixian Zhou, Shunmei Huang, Xia Zhang, Yuming Wang, Qifeng Gui and 3 more

Abstract read
In one paragraph

Article in Journal of Zhejiang University. Science. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jinyou LiZhejiang Key Laboratory for Diagnosis and Treatment of Physic-chemical and Aging-related Injuries, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Yue WuZhejiang Key Laboratory for Diagnosis and Treatment of Physic-chemical and Aging-related Injuries, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Yichen YangZhejiang Key Laboratory for Diagnosis and Treatment of Physic-chemical and Aging-related Injuries, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Lufang ChenZhejiang Key Laboratory for Diagnosis and Treatment of Physic-chemical and Aging-related Injuries, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Caihong HeZhejiang Key Laboratory for Diagnosis and Treatment of Physic-chemical and Aging-related Injuries, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Shixian ZhouZhejiang Key Laboratory for Diagnosis and Treatment of Physic-chemical and Aging-related Injuries, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Shunmei HuangZhejiang Key Laboratory for Diagnosis and Treatment of Physic-chemical and Aging-related Injuries, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Xia ZhangZhejiang Key Laboratory for Diagnosis and Treatment of Physic-chemical and Aging-related Injuries, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Yuming WangZhejiang Key Laboratory for Diagnosis and Treatment of Physic-chemical and Aging-related Injuries, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Qifeng GuiZhejiang Key Laboratory for Diagnosis and Treatment of Physic-chemical and Aging-related Injuries, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Haifeng LuState Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Qin ZhangZhejiang Key Laboratory for Diagnosis and Treatment of Physic-chemical and Aging-related Injuries, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. 1194070@zju.edu.cn, zhangqin1978@zju.edu.cn.
Yunmei YangZhejiang Key Laboratory for Diagnosis and Treatment of Physic-chemical and Aging-related Injuries, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. 1194070@zju.edu.cn.

Funding

the Medical and Health Research Project of Zhejiang Province 2023RC153the National Natural Science Foundation of China 82101665, 82271588, 82200665 and 82100795the Zhejiang Provincial Natural Science Foundation of China LY22H030009the Zhejiang Provincial Science and Technology Program of Traditional Chinese Medicine 2023ZL480
6 · The paper itself

Abstract

Gut microbial communities are likely remodeled in tandem with accumulated physiological decline during aging, yet there is limited understanding of gut microbiome variation in advanced age. Here, we performed a metagenomics-based enterotype analysis in a geographically homogeneous cohort of 367 enrolled Chinese individuals between the ages of 60 and 94 years, with the goal of characterizing the gut microbiome of elderly individuals and identifying factors linked to enterotype variations. In addition to two adult-like enterotypes dominated by

Indexed as

Escherichia coliGastrointestinal MicrobiomeMetagenomicsAgedAged, 80 and overBacteroidesChinaDiabetes Mellitus, Type 2East Asian PeopleFemaleHumansMaleMiddle AgedAgingElderly populationEnterotypeEscherichia coliEscherichia-dominated enterotypeGut microbiome

Identifiers

PMID40436643
PMCPMC12119184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.