Evidence map›Paper›PMID 40436451›Full record

SynthesisBMJ open2025

Association between patient activation, self-management behaviours and clinical outcomes in adults with type 2 diabetes: a systematic review with narrative synthesis.

Koghanadhacharve Thinakaran, Amy Ahern, Robert S Beckett, Sara F Shaida, Harriet M Wills, Rebecca Richards, Jack M Birch, Simon J Griffin, Julia Mueller

Abstract readSystematic Review
In one paragraph

Synthesis in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Koghanadhacharve ThinakaranDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, Cambridgeshire, UK.ORCID http://orcid.org/0009-0001-5495-5465
Amy AhernMRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Robert S BeckettFaculty of Biology, University of Cambridge, Cambridge, Cambridgeshire, UK.
Sara F ShaidaFaculty of Biology, University of Cambridge, Cambridge, Cambridgeshire, UK.
Harriet M WillsFaculty of Biology, University of Cambridge, Cambridge, Cambridgeshire, UK.
Rebecca RichardsMRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Jack M BirchMRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6292-1647
Simon J GriffinDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, Cambridgeshire, UK.
Julia MuellerMRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK julia.mueller@mrc-epid.cam.ac.uk.ORCID http://orcid.org/0000-0002-4939-7112

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPatient activation (PAct)-a measure assessing an individual's perceived knowledge, skills and confidence in managing their health and well-being-is often used to personalise and evaluate care, although its causal link to self-management behaviours (SMBs) and clinical outcomes remains uncertain. We aimed to synthesise the evidence on the causal association between PAct, SMBs and clinical outcomes in type 2 diabetes (T2D).

designSystematic review and narrative synthesis of data summarised in a harvest plot. DATA SOURCES: We searched Medline, Embase, CENTRAL, PsycInfo, Web of Science and CINAHL up to April 2024 for relevant English articles. ELIGIBILITY CRITERIA: We included studies of any quantitative design that reported on the association of PAct with clinical outcomes or SMBs in adult patients with T2D. DATA EXTRACTION AND SYNTHESIS: Two independent reviewers were involved, and any disagreements were discussed and resolved collaboratively. Risk-of-bias (RoB) was assessed using an adapted RoB Assessment Tool for Nonrandomised Studies. Levels of evidence were evaluated for each T2D-related outcome.

resultsWe identified 21 studies published between 2009 and 2023, including 15 cross-sectional studies and no randomised controlled trials. Eleven studies were conducted in the USA. Seventeen studies used the Patient Activation Measure questionnaire. There is moderate evidence that higher PAct scores are associated with better glycated haemoglobin levels (studies reporting on this association, n=14). There is very limited evidence that PAct improves diet (n=5) and physical activity (n=6). All other clinical outcomes and SMBs had inconclusive results due to either inconsistent or insufficient evidence, or both.

conclusionA causal relationship between PAct, clinical outcomes and SMBs in T2D cannot be established due to inconsistent evidence and a lack of high-quality studies. Thus, the use of PAct scores as a tailoring tool and an outcome measure in healthcare services requires further evaluation. PROSPERO REGISTRATION NUMBER: CRD42021230727.

Indexed as

Diabetes Mellitus, Type 2Patient ParticipationSelf-ManagementAdultHumansDiabetes Mellitus, Type 2GENERAL MEDICINE (see Internal Medicine)patient activationPatient ParticipationPUBLIC HEALTHSelf-ManagementSystematic Review

Identifiers

PMID40436451
PMCPMC12121589

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.