ArticleJournal of advanced research2026
In newly diagnosed diabetes, hyperglycemia is associated with increased brain iron deposition, measured by MRI-based Quantitative Susceptibility Mapping (QSM).
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Limbic-Predominant Cortical Magnetic Susceptibility Alterations Are Associated With Glycemic Dysregulation and Cognitive Performance in Type 2 Diabetes.CNS neuroscience & therapeutics · 2026Article
- Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cognitive impairment after cerebral ischemia-reperfusion injury: a neuroecosystem perspective.Frontiers in neurology · 2026Review
- A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes.Open medicine (Warsaw, Poland) · 2025Article
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11 authors.
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Abstract
backgroundLong-term Type 2 diabetes mellitus (T2DM) affects multiple organs and systems throughout the body, including the cardiovascular, renal, and nervous systems. In the brain, T2DM impacts brain function, leading to cognitive impairment. Due to the faster progression of cognitive decline in diabetic patients, we aim to investigate the relationship between newly diagnosed T2DM and iron deposition by brain MRI technique.
methodsWe used Quantitative Susceptibility Mapping (QSM), an advanced brain MRI technique, to non-invasively quantify iron deposition in the brain of elderly patients and healthy control subjects. In all patients, blood glucose and iron levels and their correlates parameters were evaluated.
resultsQSM revealed increased iron deposition in the putamen of elderly diabetic patients although newly diagnosed compared to healthy controls. QSM significantly correlated with high blood glucose levels and insulin resistance, but not with blood iron levels.
conclusionsResults suggest that increased iron deposition in the putamen, as analyzed by QSM, is worsened by hyperglycemia and insulin resistance, already when diabetes is newly diagnosed. Addressing this issue could improve on the one clinical inertia towards diabetes hand newly diagnosed, with an improvement in diabetes management strategies itself, and on the other hand, it could focus attention on increased putamen iron deposition as a predictive indicator of neurocognitive impairment in T2DM.
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