Research progress on immunoprotective mechanisms of enteric fever and vaccine development.

Ying Chen, Lingwei Chen, Yanzhen Lin, Yanguang Cong

Abstract readReview

In one paragraph

Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ying ChenDepartment of Clinical Laboratory, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523710, China; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523710, China.

Lingwei ChenDepartment of Clinical Laboratory, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523710, China; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523710, China.

Yanzhen LinDepartment of Clinical Laboratory, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523710, China; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523710, China.

Yanguang CongDepartment of Clinical Laboratory, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523710, China; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523710, China; Guangdong Provincial Clinical Research Center for Laboratory Medicine, China. Electronic address: ygcong@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnteric fever remains a serious global health challenge. Effective control of enteric fever depends on clean water and proper sanitation, which remains unattainable in resource-limited settings. Vaccination is therefore one of critical preventive measures. Nevertheless, there exists a paucity of systematic reviews integrating pathogenesis, the protective mechanisms, and translational vaccinology developments associated with enteric fever. AIM OF REVIEW: To enhance the mechanistic understanding of enteric fever, this review summarizes the recent advances of pathogenesis, protective immune mechanism, as well as current challenges and innovations in vaccinology. KEY SCIENTIFIC CONCEPTS OF REVIEW: CD4

Indexed as

Typhoid FeverTyphoid-Paratyphoid VaccinesVaccine DevelopmentAnimalsB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHumansVaccinationTyphoid-Paratyphoid VaccinesEnteric feverPathogenicityProtective immunityTyphoidVaccine

Identifiers

PMID40436138

DOI10.1016/j.jare.2025.05.054

PMCPMC12957850

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.