ArticleNature2025
Protein-primed homopolymer synthesis by an antiviral reverse transcriptase.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Defense-associated reverse transcriptases define an emerging class of noncanonical DNA-writing systems.Synthetic and systems biotechnology · 2026Article
- How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026Review
- Article
- Recent Advances in the Molecular Mechanisms of Bacterial Anti-Phage Defence Systems.Microbial biotechnology · 2026Article
- Coordinated RNA- and protein-templated synthesis of double-stranded DNA by a dual reverse transcriptase immune system.bioRxiv : the preprint server for biology · 2026Article
- Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase.Science (New York, N.Y.) · 2026Article
- Semirandom DNA adducts regulate a filamentous defense-associated reverse transcriptase.Nature structural & molecular biology · 2026Article
- A cost-effective 200 kV cryo-EM core facility for high resolution single particle analysis.Methods in microscopy · 2026Article
- Protein-directed nucleotide selection in the DRT3 defense system: mechanism, biological context, and constraints on programmability.Frontiers in microbiology · 2026Review
- Anti-phage defense mechanism involving phage-encoded DNA binding protein and bacterial reverse transcriptase DRT4.Nature communications · 2025Article
- Phage nuclease-mediated defense activation of the bacterial Retron-Eco7 toxin-antitoxin system.Nucleic acids research · 2025Article
- Antiviral reverse transcriptases reveal the evolutionary origin of telomerase.bioRxiv : the preprint server for biology · 2025Article
- A bacterial PrimPol-reverse transcriptase hybrid protein has a proofreading exonuclease activity that can be transferred to other reverse transcriptases.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Update of
Authors and funding
15 authors.
Stephen Tang *Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0001-5492-9796
Rimantė Žedaveinytė *Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-0738-6976
Nathaniel Burman *Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, USA.ORCID 0000-0002-3732-3159
Shishir Pandey *Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, USA.ORCID 0000-0002-7531-1538
Josephine L RamirezDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Louie M KulberDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0001-5625-7372
Tanner WiegandDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-0528-268X
Royce A WilkinsonDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT, USA.ORCID 0000-0001-8831-2081
Yanzhe MaDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Dennis J ZhangDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-6871-9842
George D LampeDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-2873-2372
Mirela BerisaMetabolomics Core, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-7347-9823
Marko JovanovicDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Blake WiedenheftDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT, USA. bwiedenheft@gmail.com.ORCID 0000-0001-9297-5304
Samuel H SternbergDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. shsternberg@gmail.com.ORCID 0000-0001-8240-9114
Funding
Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Ann Therese Bertagnolli · 2012 to 2026
$60.0MMedical Scientist Training ProgramT32GM145440 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2022 to 2026
$7.3MSurveillance genome sequencing to detect SARS-CoV-2 virus variants in MontanaP30GM140963 · NIGMS · UNIVERSITY OF MONTANA · PI BOWLER, BRUCE E · 2021 to 2025
$6.9MStructural and functional understanding of bacterial defense and viral counter defenseR35GM134867 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Blake A Wiedenheft · 2020 to 2026
$3.8MHow dynamic molecular interactions of RNA Binding Proteins drive post-transcriptional gene expression changesR35GM152258 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Marko Jovanovic · 2024 to 2026
$1.6MMechanisms of reverse transcriptase mediated phage resistance in EnterobacteriaceaeF30AI183830 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stephen Tang · 2024 to 2026
$158kCRISPR RNA-guided recognition of invading RNA activates a multipronged cell death responseF31GM153146 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI BURMAN, NATHANIEL · 2024 to 2025
$73kHoward Hughes Medical InstituteNIAID NIH HHS F30 AI183830NIGMS NIH HHS F31 GM153146NIGMS NIH HHS P20 GM103474NIGMS NIH HHS P30 GM140963NIGMS NIH HHS R35 GM134867NIGMS NIH HHS R35 GM152258NIGMS NIH HHS T32 GM145440
Abstract
Bacteria defend themselves from viral predation using diverse immune systems, many of which target foreign DNA for degradation
Indexed as
Bacterial ProteinsBacteriophagesRNA-Directed DNA PolymeraseCryoelectron MicroscopyEscherichia coliModels, MolecularPoly ARNA, UntranslatedTyrosineBacterial ProteinsPoly ARNA-Directed DNA PolymeraseRNA, UntranslatedTyrosine
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.