ArticleEBioMedicine2025
Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy.
Article in EBioMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Mapping sex-specific associations of adiposity with age-related cognitive decline and multimodal Alzheimer's pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of Long-Term Trajectories in Obesity Indices With Neuroimaging Metrics and Cognition: A Population-Based Study.Diabetes, obesity & metabolism · 2026Article
- Association of sleep duration with Alzheimer's disease and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Associations of novel visceral obesity indices (METS-VF and BRI) with dementia: the role of metabolic mediators and genetic susceptibility.Frontiers in nutrition · 2026Article
- Impact of cardiometabolic conditions on the progression from mild cognitive impairment to dementia: A large cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
17 authors.
Funding
Abstract
backgroundThe impact of high body mass index (BMI) states and associated proteomic factors on brain ageing and Alzheimer's disease (AD) remains unclear.
methodsWe sought to evaluate machine learning (ML)-based neuroimaging markers of brain age and AD-like brain atrophy in participants with obesity or overweight without diagnosed cognitive impairment (WODCI), in a harmonised study of 46,288 participants in 15 studies (the Imaging-Based Coordinate System for Aging and Neurodegenerative Diseases (iSTAGING) consortium). We also assessed the association between cognition, serum proteins, and brain ageing indices. Data were acquired between 1999 and 2020 and analysed from November 2024 onwards.
findingsThe study comprised 46,288 participants, including 24,897 females and 21,391 males, with a mean age of 64.33 years (SD = 8.13) and a mean BMI of 26.81 kg/m
interpretationThe findings demonstrate that higher BMI states are associated with accelerated brain ageing and AD-like atrophy, particularly in males, while females with normal weight demonstrated higher brain ageing and AD-like atrophy than males with normal weight. Moreover, the impact of obesity on brain ageing and AD-like brain atrophy becomes weaker with increasing age. Further research is needed to investigate sex-specific mechanisms by which weight gain influences brain ageing.
fundingNational Institute on Aging's Intramural Research Program, National Institute on Aging, Intramural Research Program.
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