ArticleJournal of the neurological sciences2025
Admitting neutrophil/lymphocyte ratio and severity of first-ever acute ischemic stroke among indigenous West Africans.
Article in Journal of the neurological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- SEASONAL VARIATION OF ACUTE STROKE IN A TROPICAL AFRICAN LOCALITY: A RETROSPECTIVE STUDY FROM SUB-SAHARAN AFRICA.Annals of Ibadan postgraduate medicine · 2025Article
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7 authors.
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Abstract
backgroundWe hypothesized that the neutrophil-lymphocyte ratio (NLR) alone, compared with a combination of the NLR and National Institutes of Health Stroke Scale score (NIHSS) [(NLR + NIHSS)], may help identify persons with severe stroke in a low-resource setting, with few personnel trained to assess the NIHSS score.
methodsWe studied 212 participants which included 106 patients with clinico-radiologic diagnosis of AIS and 106 comparative group. At inception, patients with clinico-laboratory features of sepsis, or infection were excluded. Stroke severity was assessed using the Stroke Levity Scale (SLS) and NIHSS scores while NLR was obtained at admission. Factors [beta coefficient (95 % CI)] associated with stroke severity (SLS ≤ 5) were reported using a multi-variable linear regression. A Receiver Operating Characteristics (ROC) curve was used to test the discriminatory ability of the NLR compared with the NLR + NIHSS score in identifying patients with severe stroke (using the SLS score).
resultsMedian (IQR) NLR was 2.87 (3.0) among cases and 0.98(0.6) for controls, (p < 0.001). The median (IQR) SLS score of stroke participants was [8.0 (6.0)]. Independent predictors of severe ischemic stroke were baseline NLR [-0.53 (-0.79, -0.26)], admitting GCS [0.31 (0.09, 0.53)], and infarct volume [-0.07 (-0.10, -0.03)]. The NLR alone had an AUC (95 % CI) of 0.82 (0.72-0.92) compared to the NLR + NIHSS score with 0.85 (0.76-0.94).
conclusionHigh admitting NLR is independently associated with severe AIS. In a low-resource setting, with few personnel trained to assess the NIHSS score, the NLR alone may help identify patients with severe AIS.
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