Evidence map›Paper›PMID 40435278›Full record

ArticlePloS one2025

Bio-inspired cryptography based on proteinoid assemblies.

Panagiotis Mougkogiannis, Essam Ghadafi, Andrew Adamatzky

Abstract read
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Proteinoid Computing on Olivine Substrates.Langmuir : the ACS journal of surfaces and colloids · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Panagiotis MougkogiannisUnconventional Computing Lab, University of the West of England, Bristol, United Kingdom.ORCID 0000-0003-1710-4917
Essam GhadafiSchool of Computing, Newcastle University, Newcastle-Upon-Tyne, United Kingdom.
Andrew AdamatzkyUnconventional Computing Lab, University of the West of England, Bristol, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present an innovative cryptographic technique inspired by the self-assembly processes of proteinoids-thermally stable proteins that form spontaneously under prebiotic conditions. By emulating the deterministic yet complex interactions within proteinoid assemblies, the proposed method generates secure encryption keys and algorithms. We measure the unique electrical properties of proteinoid microspheres. Their capacitance values range from -656.6 to 434.9 nF. Then, we convert these measurements into encryption keys using the formula [Formula: see text]. The approach harnesses the inherent unpredictability of proteinoid behavior to create a robust and adaptable encryption framework resilient to cryptanalytic attacks. The encryption process uses modular multiplication: [Formula: see text] [Formula: see text] [Formula: see text]. This changes plaintext into ciphertext. The security relies on electrical signatures that depend on the composition. Experimental results show that this bio-inspired system aligns with contemporary encryption standards, offering significant benefits in key generation and distribution. Our implementation has a linear computational complexity of O(n). It offers security levels ranging from 8 to 128 bits, based on composition. Additionally, it is energy efficient, performing about 200 operations per joule. Statistical analysis further affirms the high randomness of the generated keys, highlighting the potential of biological processes in advancing cryptographic security.

Indexed as

Computer SecurityProteinsAlgorithmsProteins

Identifiers

PMID40435278
PMCPMC12118996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.